Given the excellent survival rates for early-stage Hodgkin lymphoma (HL), the young age of many patients, and concerns regarding acute and late treatment-related toxicities, there is a desire to have a predictive tool that enables therapy to be tailored toward the individual patient. Early (or interim) (18)F-fluorodeoxyglucose positron emission tomography with computerized tomography (FDG-PET/C...

BACKGROUND Announcements of interim analyses of a clinical trial convey information about the results beyond the trial's Data Safety Monitoring Board (DSMB). The amount of information conveyed may be minimal, but the fact that none of the trial's stopping boundaries has been crossed implies that the experimental therapy is neither extremely effective nor hopeless. Predicting success of the ongo...

The new generation of weather observatory satellites, namely Global Precipitation Measurement (GPM) constellation satellites, is the lead observatory of the 10 highly advanced earth orbiting weather research satellites. Indeed, GPM is the first satellite that has been designed to measure light rain and snowfall, in addition to heavy tropical rainfall. This work compares the final run of the Int...

Atmospheric blocking events are known to locally explain a large part of climate variability. However, despite their relevance, many current climate models still struggle to represent the observed blocking statistics. In this study, simulations of the global climate model EC-Earth are analysed with respect to atmospheric blocking. Seventeen simulations map the uncertainty space defined by the t...

AIM Maxillectomy often results in a high level of morbidity with significant psychological and functional implications for the patient. Such disabilities include inability to masticate, deglutition, and speech disturbance. Unfortunately, little is known about the nature of the speech disturbance and the influence of the class of surgical defects in this group of patients. The aims of the presen...