recently, inflammation has been found to be a significant factor in the development of schizophrenia (scz). the aim of the present research was to investigate whether interleukin-33 (il-33, omim: 608678) gene polymorphism (rs11792633, c/t) is associated with the development of scz or not.dna was isolated from the serum of 70 patients with scz and 70 healthy controls. the pcr based method was us...

The recently recognized cytokine interleukin-33 and its receptor ST2 play a favorable role during atherogenesis by inducing a Th1 --> Th2 shift of the immune response. IL-33 also protects the failing human heart from harmful biomechanical forces which lead to cardiomyocyte hypertrophy and exaggerated interstitial fibrosis. IL-33 inevitably displays side effects common to other Th2 cytokines, th...

PURPOSE The authors discovered a genetic association between the ST2L gene and atopy. The ST2L gene encodes a membrane-bound functional marker for Th2 cells. Recently, a novel Th2 cytokine, interleukin-33 (IL-33), was discovered to be a specific ligand for ST2L. The authors investigated the role of IL-33 in chronic allergic conjunctivitis. METHODS Immunohistochemical analysis was carried out ...

Interleukin- (IL-) 33 is a widely expressed cytokine present in different cell types, such as epithelial, mesenchymal, and inflammatory cells, supporting a predominant role in innate immunity. IL-33 can function as a proinflammatory cytokine inducing Th2 type of immune response being involved with the defense against parasitic infections of the gastrointestinal tract. In addition, it has been p...

BACKGROUND Interferon-γ (IFN-γ) plays a crucial role in Mycobacterium tuberculosis induced pleural responses. Interleukin (IL)-33 up-regulates the production of IFN-γ. We aimed to identify whether an association between pleural IL-33 levels and tuberculous pleurisy exists and determine its diagnostic value. METHODS Pleural IL-33, ST2 (a receptor of IL-33), adenosine deaminase (ADA), and IFN-γ...

Interleukin (IL)-33, a member of the IL-1 family of cytokines, is produced when epithelial and endothelial cells are exposed to stimuli. Hematopoietic cells such as macrophages also produce IL-33. IL-33 is considered to function as an 'alarmin', activating various immune cells through its receptor ST2, which leads to the production of various molecules. The IL-33-induced production of pro-infla...

nterleukin-33 (IL-33) is a member of the IL-1 superIfamily and activates group 2 innate lymphoid cells (ILC2), mast cells, and their progenitors. Studies indicate that ILCs, which secrete copious amounts of IL-5 and IL-13 in response to IL-33, play critical roles in directing the development of type-2 immunity and allergic inflammation. In this issue of Cellular and Molecular Gastroenterology a...

Aims. Previous evidence has proved that interleukin-31 (IL-31) and interleukin-33 (IL-33) can be potential markers in some cancers' formulation. We aimed to determine the potential role of IL-31 and IL-33 in prognosis of endometrial cancer patients. Methods. Serum samples were collected from 160 patients with endometrial cancer and 160 healthy controls. The ELISA kits (Raybio® Systems) specific...