The β roll molecules with sequence (GAGAGAGQ)10 stack via hydrogen bonding to form fibrils which have been themselves been used to make viral capsids of DNA strands, supramolecular nanotapes and pH-responsive gels. Accelerated molecular dynamics (aMD) simulations are used to investigate the unfolding of a stack of two β roll molecules, (GAGAGAGQ)10, to shed light on the folding mechanism by whi...

Background: &beta-thalassemia is the most common monogenic disorder in human. The (CT) polymorphism at -158 upstream region of the &gammaG-globin gene and pharmacological factors such as hydroxyurea have been reported to influence &gamma-globin gene expression and the severity of clinical symptoms of &beta-thalassemia. Methods: In the present study, 51 &beta-thalassemia intermediate patients w...

Fix a graph G , list-assignment L for and -colorings α β . An -recoloring sequence, starting from recolors single vertex at each step, so that resulting intermediate coloring is proper -coloring. sequence transforms to if its initial final We prove there exists an most constant number of times (i) triangle-free planar 7-assignment, or (ii) mad ( ) < 17 / 5 6-assignment (iii) 22 9 4-assignment. ...

Tethering known drugs to a metalorganic moiety is an efficient approach for modulating the anticancer, antibacterial, and antiparasitic activity of organometallic complexes. This study focused on synthesis evaluation new dinuclear ruthenium(II)–arene compounds linked several antimicrobial such as dapsone, sulfamethoxazole, sulfadiazine, sulfadoxine, triclosan, metronidazole, ciprofloxacin, well...

Mackenzie, A., Studies on the Biosynthetic Pathways of Clavulanic Acid and Cephamycin C in Streptomyces clavuligerus. Doctoral dissertation. ISSN 1652-6880 ISBN 978-91-576-7318-3 The discovery of penicillin, a β-lactam antibiotic, changed the way humans thought about infectious disease. Unfortunately, the widespread use of antibiotics has lead to a concomitant increase in bacterial resistance t...

In this paper, we introduce and study  a mapping from the collection of all  intermediate rings of $C(X)$ to the collection of all  realcompactifications of $X$ contained in $beta X$. By establishing the relations between this mapping and its converse,  we give a different approach to the main statements of De et. al. Using these, we provide different answers to the   four basic questions...

A direct and selective synthesis of α,β-unsaturated piperidones by a new palladium-catalyzed cascade carbonylation is described. In the presented protocol, easily available propargylic alcohols react with aliphatic amines to provide broad variety interesting heterocycles. Key success this transformation remarkable catalytic cleavage present carbon–carbon triple bond using specific catalyst 2-di...

DNA polymerase (Pol) β maintains genome fidelity by catalyzing DNA synthesis and removal of a reactive DNA repair intermediate during base excision repair (BER). Situated within the middle of the BER pathway, Pol β must efficiently locate its substrates before damage is exacerbated. The mechanisms of damage search and location by Pol β are largely unknown, but are critical for understanding the...

Purpose : This study aimed to examine the relationship between sleep quality and its influencing factors in patients with coronary artery disease (CAD).Methods descriptive correlational included 130 CAD admitted cardiology department of a general hospital B City September 2019 February 2020. Data were collected using structured questionnaires research instruments measure quality, anxiety, depre...