The role of the elimination of ring B and/or the modification of ring C of colchicine in tubulin binding kinetics and thermodynamics has been characterized, using four different molecules. These ligands are colchicine (COL); 2-methoxy-5-(2',3',4'-trimethoxyphenyl)-2,4,6-cycloheptatrien-1-on e (MTC), in which the central ring B has been reduced to one bond; allocolchicine (ALLO), in which ring C...

Of the tetracyclines, minocycline is unique in causing a significant incidence of a lupus-like syndrome and autoimmune hepatitis. It is also unique among the tetracyclines in having a para-N,N-dimethylaminophenol ring. Many drugs that cause autoimmune reactions are oxidized to reactive metabolites by the myeloperoxidase (MPO) system of macrophages. In this study, we showed that minocycline is o...

Let $R$ be a 2-torsion free semiprime ring with extended centroid $C$, $U$ the Utumi quotient ring of $R$ and $m,n>0$ are fixed integers. We show that if $R$ admits derivation $d$ such that $b[[d(x), x]_n,[y,d(y)]_m]=0$ for all $x,yin R$ where $0neq bin R$, then there exists a central idempotent element $e$ of $U$ such that $eU$ is commutative ring and $d$ induce a zero derivation on $(1-e)U$. ...

The ‘RING-between-RING’-type E3 ubiquitin ligase HOIP acts via a novel RING/HECT-hybrid ubiquitin transfer mechanism and catalyses the formation of linear ubiquitin chains by non-covalently binding the acceptor ubiquitin. But in the absence of a binding partner, HOIP is autoinhibited. This explains why assembly of either HOIP/ HOIL-1L or HOIP/SHARPIN is required to catalyse linear chain formati...

Abstract— We have developed an alternative method for the synthesis of analog natural retinal, which contains p -fluorophenyl fragment instead trimethylcyclohexene ring. The proposed scheme target all-E -isomer retinoid consists using C 5 -phosphonate that terminal nitrile group under Horner–Emmons reaction conditions. It has been shown this is more efficient and provides a higher total yield p...

A seminear-ring is a generalization of ring. In ring theory, if with the multiplicative identity, then endomorphism module isomorphic to . Let be seminear-ring. Here, we can construct set from itself denoted by We show that seminear-ring, also over addition and composition function. will apply congruence relation get quotient endomorphism. Furthermore, between c-ideal relations. So, c-ideal.

α-Imino gold carbenoid species have been recognized as key intermediates in a plethora of processes involving gold-activated alkynes. Here, we explored the pathways Au(I)-catalyzed [3 + 2] reaction between mild nucleophiles: anthranil, 1,2,4-oxadiazole, or 4,5-dihydro-1,2,4-oxadiazole, and an ynamide, PhC≡C-N(Ts)Me, proceeding via formation aforementioned α-imino carbene intermediate which, aft...

A crossed molecular beams experiment with ground state boron atoms, B((2)P(j)), and diacetylene, C(4)H(2)(X(1)Σ(g)(+)), was conducted at a collision energy of 21.1 ± 0.3 kJ mol(-1) under single collision conditions and combined with electronic structure calculations on the (11)BC(4)H(2) potential energy surface. Our combined experimental and computational studies indicate that the reaction proc...

in this paper, we study some ring theoretic properties of the amalgamated duplication ring $rbowtie i$ of a commutative noetherian ring $r$ along an ideal $i$ of $r$ which was introduced by d'anna and fontana. indeed, it is determined that when $rbowtie i$ satisfies serre's conditions $(r_n)$ and $(s_n)$, and when is a normal ring, a generalized cohen-macaulay ring and finally a filter ring.

Quinolones rapidly kill bacteria by two mechanisms, one that requires protein synthesis and one that does not. The latter, which is measured as lethal action in the presence of the protein synthesis inhibitor chloramphenicol, is enhanced by N-1 cyclopropyl and C-8 methoxy substituents, as seen with the highly lethal compound PD161144. In some compounds, such as levofloxacin, the N-1 and C-8 sub...