Intermittent positive pressure respiration (IPPR) is best accomplished with a completely closed system during the inspiratory phase, so that all gas squeezed out of the reservoir bag will go to the patient's lungs. Under these conditions ventilation is volume-controlled. A low pressure in the system during the expiratory and resting phases will have least adverse effect on the patient; however,...

The aim of this study was to provide information on heart rate and blood pressure responses during a 3-week intermittent hypoxia breathing program in COPD patients. Sixteen participants with COPD symptoms were randomly assigned to a hypoxia or control group and completed a 3-week intermittent hypoxia breathing program (five sessions per week, each consisting of three to five breathing cycles, e...

Chronic intermittent hypoxia is considered to play an important role in cardiovascular pathogenesis during the development of obstructive sleep apnea (OSA). We used a well-described OSA rat model induced with simultaneous intermittent hypoxia. Male Sprague Dawley rats were individually placed into plexiglass chambers with air pressure and components were electronically controlled. The rats were...

BACKGROUND Intermittent negative pressure (INP) applied to the lower leg and foot increases foot perfusion in healthy volunteers. The aim of the present study was to describe the effects of INP to the lower leg and foot on foot macro- and microcirculation in patients with lower extremity peripheral arterial disease (PAD). METHODS In this experimental study, we analyzed foot circulation during...

muslims all over the world fast in the holy month of ramadan. fasting means abstinence from drinking any liquids, eating, smoking and taking anything parenterally.  it is intermittent in nature from the start of dawn to end at dusk. fasting has various physiological effects on different biological parameters of the human body. previous studies that look at effect of ramadan fasting on blood pre...

One of the major manifestations of obstructive sleep apnea is profound and repeated hypoxia during sleep. Acute hypoxia leads to stimulation of the peripheral chemoreceptors, which in turn increases sympathetic outflow, acutely increasing blood pressure. The chronic effect of these repeated episodic or intermittent periods of hypoxia in humans is difficult to study because chronic cardiovascula...

Peripheral circulation is severely compromised in the advanced stages of peripheral arterial disease. Recently, it was shown that the application of -40 mmHg intermittent negative pressure (INP) to the lower leg and foot enhances macro- and microcirculation in healthy volunteers. In this case report, we describe the effects of INP treatment on four patients with lower limb ischemia and hard-to-...