Sulfonamides are known to alter the intestinal flora of animals, with a consequent change in the synthesis of certain vitamins by the intestinal bacteria (l-5). This altered synthesis may in turn lead to an increased dietary vitamin requirement for some animals or invoke new requirements in others. For example, the inclusion of 1 per cent of sulfasuxidine in the diet of chicks increases their f...

It is well known that some intestinal bacteria, such as Escherichia coli, can produce a remarkable amount of molecular hydrogen (H(2)). Although the antioxidant effects of H(2) are well documented, the present study examined whether H(2) released from intestinally colonized bacteria could affect Concanavalin A (ConA)-induced mouse hepatitis. Systemic antibiotics significantly decreased the leve...

An ortho-nitrophenol solution was injected into the intestine which had been removed from an anesthetized mouse by placing a ligature at the duodenum and at the rectum. The intestine was then incubated in Ringer's solution at 37•Ž and the ortho-nitrophenol was found to be reduced to ortho aminophenol. At the same time, it was found that ortho-nitrophenol which was incubated with the intestinal ...

Lactobacillus acidophilus belongs to the genus Lactobacillus, Gram-positive bacteria, which mainly colonize small intestine of animals, can secrete anti-biotin substances, inhibit growth and reproduction some intestinal pathogenic thereby regulating Intestinal flora, strengthen absorption utilization feed nutrients, improve resistance, promote animal growth, so it is widely used in livestock po...

Escherichia coli K-12 Hfr and F- strains were successively implanted in axenic chicks. Conjugation with exchanges of chromosomal genes occurred with high frequencies in the gut of the chicks and could continue as long as fertile strains coexisted in this environment. Almost all of the expected recombinant types were recovered in the feces under these experimental conditions. Furthermore, these ...

To investigate arthritis-inducing properties of Eubacterium species, which are major residents of the human intestinal flora, cell wall fragments (CWF) of several Eubacterium strains were prepared and tested in an animal model. After a single intraperitoneal injection in the rat, CWF of E. aerofaciens, E. contortum, and E. lentum induced a chronic polyarthritis. E. limosum and E. tortuosum CWF ...

The gut-associated lymphoid tissue (GALT) is constantly exposed to a variety of Ags and must therefore decipher a large number of distinct signals at all times. Responding correctly to each set of signals is crucial. When the GALT receives signals from the intestinal flora or food Ags, it must induce a state of nonresponsiveness (mucosal tolerance). In contrast, when pathogenic bacteria invade ...

The neonatal intestinal immune system is still undergoing development at birth, leading to a higher susceptibility to mucosal infections. In this study, we investigated the effect of poly(I:C) on controlling enteric infection by the protozoan Cryptosporidium parvum in neonatal mice. After poly(I:C) administration, a rapid reduction in parasite burden was observed and proved to be dependent on C...

OBJECTIVES The aim of this study was to determine the anaerobic spectrum of activity of REP3123, a novel diaryldiamine that inhibits bacterial methionyl-tRNA synthetases in Gram-positive bacteria. METHODS Fifty recent clinical isolates of Clostridium difficile from patients diagnosed with C. difficile infection and 223 other intestinal normal flora anaerobes were tested for their susceptibili...

Intestinal microecology refers to the interaction between host and microorganisms in human intestinal tract, which is composed mainly of flora. microflora affects physiological pathological changes through metabolic activity interaction. Precancerous lesion liver a potential benign disease, may lead malignant transformation liver. It intermediate stage from transformation. Recent studies have s...