Mechanisms of formation and growth of intracranial aneurysms are poorly understood. To investigate the pathophysiology of intracranial aneurysms, an animal model of intracranial aneurysm yielding a high incidence of large aneurysm formation within a short incubation period is needed. We combined two well-known clinical factors associated with human intracranial aneurysms, hypertension and the d...

The aim of the present study was to ascertain whether aminoguanidine attenuated intracranial hypertension and cerebral ischemic injury in experimental heatstroke. Urethane-anesthetized rats were exposed to heat stress (ambient temperature of 43 degrees C) to induce heatstroke. Control rats were exposed to 24 degrees C. Mean arterial pressure, cerebral perfusion pressure, and cerebral blood flow...

Chronic headaches, associated with papilledema and pulsatile tinnitus without any neuroradiologic, cytobiochemical or cerebrospinal fluid abnormalities are suggestive of idiopathic intracranial hypertension (IIH). However the absence of the papilledema does not rule out this diagnosis. The reason why some patients do not develop papilledema in IIH is ignored, however there are some hypotheses c...

creased dural venous sinus pressure or a defect in the arachnoid villi. The possibility of dural venous sinus thrombosis was ruled out in this case by MR examination that showed the venous sinuses to be widely patent. As suggested by the MR findings in this patient, low hemoglobin levels may result in compensatory changes in cerebral blood volume, leading to increased intracranial pressure. Thi...

Idiopathic intracranial hypertension, also known as pseudotumor cerebri, is an unexplained increase in intracranial pressure associated with permanent severe visual loss in 25% of cases and debilitating headaches. The condition is often associated with obesity. The Idiopathic Intracranial Hypertension Treatment Trial, a large, randomized, collaborative clinical trial, evaluated the efficacy of ...

We examined 4 patients in the past 6 years who were first seen at our institution because of metamorphopsia and who were eventually diagnosed as having idiopathic intracranial hypertension (IIH). Idiopathic intracranial hypertension is a condition of elevated intracranial pressure that occurs primarily in young women. Neuroimaging findings and cerebrospinal fluid (CSF) indices are normal. Its c...

Pseudotumor cerebri or benign intracranial hypertension is characterized by increased intracranial hypertension without evidence of a mass lesion or ventricular obstruction. Symptoms are mainly headache and papilledema. If untreated, papilledema can cause progressive irreversible visual loss and optic atrophy. Usually occurs in obese women and in the childbearing years. It is a diagnosis of exc...

Isolated intracranial hypertension is a common manifestation of intracranial sino-venous thrombosis (ISVT). Markedly elevated intracranial tension presents with unusual features including cranial neuropathies and radiculopathy. We report two cases with ISVT, which presented with headache, papilledema, progressive visual loss, complete ophthalmoplegia and flaccid areflexic quadriparesis along wi...

INTRODUCTION Idiopathic intracranial hypertension is a rare condition characterized by increased intracranial pressure without clinical, laboratory, or radiological evidence of intracranial pathology. Early management could prevent irreversible outcomes. CASE PRESENTATION A 17-year-old single Arabian female of Arab origin presented with a 2-day complaint of horizontal diplopia and transient v...