Allosteric proteins use energy derived from ligand binding to promote a global change in conformation. The "gating" equilibrium constant of acetylcholine receptor-channels (AChRs) is influenced by ligands, mutations, and membrane voltage. We engineered AChRs to have specific values of this constant by combining these perturbations, and then calculated the corresponding values for a reference co...

This paper studies the implications for monetary policy of heterogeneous expectations in a New Keynesian model. The assumption of rational expectations is replaced with parsimonious forecasting models where agents select between predictors that are underparameterized. In a Misspecification Equilibrium agents only select the best-performing statistical models. We demonstrate that, even when mone...

Equilibrium ‡ow in a physical network with a large number of users (e.g., transportation, communication and computer networks) need not be unique if the costs of the network elements are not the same for all users. Such di¤erences among users may arise if they are not equally a¤ected by congestion or have di¤erent intrinsic preferences. Whether or not, for all assignments of strictly increasing...

Point defects play an important role in determining the structural stability and mechanical behavior of intermetallic compounds. To help quantitatively understand the point defect properties in these compounds, we developed PyDII, a Python program that performs thermodynamic calculations of equilibrium intrinsic point defect concentrations and extrinsic solute site preferences in intermetallics...

in this paper, a five–dimensional mathematical model is proposed for the transmission dynamics of hiv/aids within a population of varying size. in writing the model, we have divided the population under consideration into five sub classes of susceptible, infective, pre-aids, aids related complex and that of aids patients. the model has two non- negative equilibria namely, a disease free and the...

the interaction between benzo-15-crown-5 (b15c5), dibenzo-18-crown-6 (db18c6), dibenzyl-daza-18crown-6 (dbzda18c6), n-phenyl-aza-15-crown-5 (npha15c5) and dibenzopyridine-18-crown-6 (dbpy18c6) with π-acceptor 2,3-dichloro-5,6-dicyanobenzoquinone (ddq) in chloroform solution was studied spectrophotometrically. the interaction of b15c5-ddq and db18c6-ddq caused the formation of 1:1 charge transfe...

We study how the Einstein relation between spontaneous fluctuations and the response to an external perturbation holds in the absence of currents, for the comb model and the elastic single-file, which are examples of systems with subdiffusive transport properties. The relevance of non-equilibrium conditions is investigated: when a stationary current (in the form of a drift or an energy flux) is...

Recent experiments have confirmed the importance of nuclear quantum effects even in large biomolecules at physiological temperature. Here we describe how the path integral formalism can be used to describe rigorously the nuclear quantum effects on equilibrium and kinetic properties of molecules. Specifically, we explain how path integrals can be employed to evaluate the equilibrium (EIE) and ki...

A hypothetical time variation of the gravitational constant G would cause neutron star matter to depart from beta equilibrium, due to the changing hydrostatic equilibrium. This induces nonequilibrium beta processes, which release energy that is invested partly in neutrino emission and partly in internal heating. Eventually, the star arrives at a stationary state in which the temperature remains...