Among patients undergoing heart transplantation, Aspergillus is the opportunistic pathogen with the highest attributable mortality. The median time of onset from transplantation for invasive pulmonary aspergillosis (IPA) was 46 days, but the median time to first positive culture result was 104 days among patients with Aspergillus colonization but no invasive disease. Most patients with IPA pres...

Aspergillus fumigatus, a ubiquitous fungus, causes a wide spectrum of clinical conditions ranging from allergic to invasive aspergillosis depending upon the hosts' immune status. Several animal models have been generated to mimic the human clinical conditions in allergic and invasive aspergillosis. The onset, duration and severity of the disease developed in models varied depending on the anima...

The occurrence of invasive pulmonary aspergillosis (IPA) in critically ill patients with viral pneumonitis has increasingly been reported recent years. Influenza-associated (IAPA) and COVID-19-associated (CAPA) are the two most common forms this fungal infection. These diseases cause high mortality patients, whom were previously immunocompetent. pathogenesis IAPA CAPA is still not fully underst...

We evaluated autopsy-proven invasive fungal infections (IFI) in patients with hematologic malignancies over three periods (1989-1993, 1994-1998, and 1999-2003). The autopsy rate declined significantly (67%-34%-26%, respectively p<0.0001). IFI were identified in 314 (31%) of 1017 autopsies. Most IFI (75%) were not diagnosed antemortem. The prevalence of invasive mold infections increased signifi...

ral fistula complicating invasive pimlmonary aspergillosis. Am Rev Respir Dis 1982; 126:163-65 4 Martino P, Cirmenia C, Venditti NI, Micozzi A, Gentile C, Raccah R, et al. Spontaneous pneimmno)tho)ra.x co)mphicating piml monary mycetoma in a patient with acute letmkemia. Rev Infect Dis 1990; 12:611-17 5 Ricketti AJ, Greenberger PA, Classroth J. Spontamseoms pneumo thorax in allergic bronchopulm...

results the results of energy-dispersive x-ray demonstrated that the purified nps consisted of only se. in addition, transmission electron micrographs showed that 120- to 140-nm spherical se nps were the most common. an antifungal assay was performed with a standard clinical and laboratory standards institute broth microdilution method. minimum inhibitory concentration (mic) measurements of the...

BACKGROUND Despite advances in the treatment, the morbidity and mortality rate associated with invasive aspergillosis remains unacceptably high (70-90%) in immunocompromised patients. Amphotericin B (AMB), a polyene antibiotic with broad spectrum antifungal activity appears to be a choice of treatment but is available only as an intravenous formulation; development of an oral formulation would ...