The anthracycline anticancer agent doxorubicin has been recognised to induce a dose-dependent cardiotoxicity. The chronic form of such complication is characterized by an irreversible cardiac damage and congestive heart failure. Although the pathogenesis of anthracycline cardiotoxicity seems to be multifactorial, the pivotal role has been attributed to reactive oxygen species formation. Because...

Chronic metabolic acidosis has been previously shown to stimulate protein degradation. To evaluate the effects of chronic metabolic acidosis on nitrogen balance and protein synthesis we measured albumin synthesis rates and urinary nitrogen excretion in eight male subjects on a constant metabolic diet before and during two different degrees of chronic metabolic acidosis (NH4Cl 2.1 mmol/kg body w...

Thyroid hormone (TH) action and metabolism require hormone transport across cell membranes. We have investigated the possibility that TH are substrates of amino acid transport (System L) mediated by heterodimers of 4F2 heavy-chain (hc) and the light-chain (lc) permease IU12. Co-expression of 4F2hc and IU12 cDNAs injected into Xenopus oocytes induces saturable, Na(+) -independent transport of tr...

The present study was carried out for 7 days on four adult low-lander single-humped camels to know the effectof endurance load exercise physiological, biochemical, hormonal, and inflammatory cytokines at high altitude.A significant 1.5 3 fold increase observed in physiological responses, viz. respiration heart rate onthe 1st 7th day after exercise. Further, serum triglycerides levels were signi...

A 44-year-old man presented with an enlarged painful lower anterior neck lump elevated serum concentrations of free thyroxine (T4) and tri-iodothyronine (T3), alongside the presence antithyroid peroxidase antibodies. Prior to presentation, patient was demonstrating recovery from a SARS-CoV-2 infection that required sedation, intubation, invasive ventilation in intensive care unit (ICU) for 11 d...

The iodothyronine deiodinases are selenoenzymes that regulate the activity of thyroid hormone via specific inner- or outer-ring deiodination. In humans, type 1 deiodinase (D1) is highly expressed in the liver, but the mechanism by which its gene expression is regulated remains to be elucidated. Liver X receptor α (LXRα), a transcription factor of the nuclear receptor superfamily, is highly expr...