Visceral leishmaniasis is a serious public health problem. Leishmania infantum is one of its causative agents. LCR1 is an immunogen from L. infantum. Antibodies against this protein have been detected in visceral leishmaniasis patients. The aim of this study was to define the antibody and cellular immune responses against LCR1 in Iranian visceral leishmaniasis patients and recovered individuals...

The exact role of dopamine transporter gene (DAT1) in the pathogenesis of bipolar disorder type 1 (BD) is not understood. In the present study, we aimed to evaluate the possible association between 30, 40 and 63 bp variable number tandem repeat (VNTR) polymorphisms of DAT1 gene and the risk of type 1 (BD) in a sample of Iranian population. This case-control study was performed on 152 BD patient...

To visualize the structure of Iranian chemistry scientific publications in SciSearch, 43 Iranian and International chemists were identified. They were the highly cited scientists in 7682 Iranian chemistry publications (defined as an article with at least one Iranian author address) indexed in Science Citation Index during the period from 1990 to 2006. Co-citation data for these authors from the...

STATEMENT OF THE PROBLEM Langerhans cell histiocytosis is a rare disease with unknown pathogenesis and is characterized by local or disseminated proliferation of Langerhans cells. There is no previous investigation on prevalence of oral Langerhans cell histiocytosis in Iranian population. PURPOSE The purpose of this study was to assess the relative frequency of oral Langerhans cell histiocyto...

BACKGROUND Breast Cancer (BC) is the most common cancer in Iranian women, meanwhile the Iranian patients are relatively young. Granzyme H (GZMH) is a functional cytotoxic serine protease of NK cell granules, which expands the cell death-inducing repertoire of innate immune system. GZMH is constitutively and highly expressed in human NK cells, in order to possess chymotrypsin-like (chymase) enzy...

Gastric cancer is one of the most common causes of cancer deaths all over the world. Every year, more than 870 thousand new cases are reported throughout the world and more than 650 thousand people die from this type of cancer (Parkin, 1998). According to the latest statistics of Iran Cancer Research Center, gastric cancer is the most common cancer among Iranian men and the third most common ca...

The mismatch repair system (MMR) is a post-replicative DNA repair mechanism whose defects can lead to cancer. The MSH3 protein is an essential component of the system. We postulated that MSH3 gene polymorphisms might therefore be associated with prostate cancer (PC). We studied MSH3 codon 222 and MSH3 codon 1036 polymorphisms in a group of Iranian sporadic PC patients. A total of 60 controls an...

OBJECTIVE To analyze the association between TREM2 exon 2 variants and late-onset (sporadic) Alzheimer's disease (AD) in an elderly Iranian population. MATERIALS AND METHODS Exon 2 of TREM2 in a total of 131 AD patients and 157 controls was genotyped using polymerase chain reaction and Sanger sequencing. Fisher's exact test was used to compare the allele and genotype frequency between the 2 s...

OBJECTIVE In schizophrenia, neurocognitive functions are one to two standard deviations below the normal controls and these deficits have a significant relationship with overall functioning and poor outcome. According to this fact, it is important to investigate the factors that effect neurocognition in schizophrenic patients. This study was carried out to demonstrate the relationship between a...

Background and aims. The aim of the present study is to determine the incidence of MTHFR C677 T and A1298C muta-tions in Iranian patients with cleft lip and/or cleft palate. Materials and methods. We screened 61 Iranian patients with cleft lip and/or cleft palate for mutations in the two alleles of MTHFR gene associated with cleft lip and/or palate: A1298C and C677T, using Polymerase Chain Reac...