OBJECTIVE To determine the association of changes in anterior chamber angle and anterior chamber depth (ACD) with intraocular pressure (IOP) reduction after uncomplicated phacoemulsification. METHODS In this prospective study, subjects underwent phacoemulsification with foldable lens implantation. Anterior chamber angle grading of 2 or less (Shaffer grading) in 3 or all quadrants was consider...

A 5-week-old male presented with Peters' anomaly. Corneal transplantation was deferred and the patient underwent an optical sector iridectomy in his better eye with central leukoma and iridocorneal adhesions. At six months following surgery, there was a decrease in corneal opacity. The most recent ophthalmic examination was performed at age 42 months. The cornea was considerably clearer, and th...

The metabolic syndrome (MetS) produces low-grade inflammation, endothelial dysfunction, platelet hyperactivity, oxidative stress and ultimately contributes to cardiovascular disease (CVD) development. Fatty acids such as n-3 n-6, monounsaturated, conjugated, highly unsaturated, short-chain types, their metabolism can impact the development of MetS associated features. Furthermore, quality quant...

BACKGROUND Endothelial dysfunction and injury are considered to contribute considerably to the development and progression of atherosclerosis. It has been suggested that intense exercise training can increase the number and angiogenic properties of early endothelial progenitor cells (EPCs). However, whether exercise training stimulates the capacity of early EPCs to promote repair of endothelial...

Down syndrome is the most common genetic cause of mental retardation in humans, occurring in one out of 700 live births. Epidemiological studies suggest that although individuals with Down syndrome have an increased risk of infant cardiovascular malformation, muscle hypotonia, lymphatic edema, and leukemia, noteworthy they have a considerably reduced incidence of most solid tumor, atheroscleros...

BACKGROUND Glaucoma is a leading cause of blindness worldwide. Nonetheless, the mechanism of its pathogenesis has not been well-elucidated, particularly at the molecular level, because of insufficient availability of experimental genetic animal models. METHODOLOGY/PRINCIPAL FINDINGS Here we demonstrate that deficiency of Vav2 and Vav3, guanine nucleotides exchange factors for Rho guanosine tr...

The assessment of anterior segment structures has become an important consideration for the planning of ocular refractive and cataract surgery, as well as for diagnosing and treating glaucoma and assessing corneal health. This assessment is typically performed by means of slit lamp biomicroscopy in clinical applications. An objective quantitative assessment of anterior segment structures is not...

In 1989, Koslov et al. described ‘deep sclerectomy’ (DS): an ‘en-bloc’ resection of the external wall of Schlemm’s canal, along with corneal stroma adjacent to the anterior trabeculum and, more anteriorly, exposure of Descemet’s membrane over 4–5 mm. These structures were removed with a slice of sclera beneath a superficial scleral flap: hence the term deep sclerectomy. In 1998, Vaudaux et al. ...

INTRODUCTION Selective laser trabeculoplasty (SLT) is applied to reduce intraocular pressure in primary open angle glaucoma therapy. It selectively subjects trabecular pigmented cells to a pulsed, frequency-doubled Nd:YAG laser. The biostimulatory effect on trabecular macrophages was also postulated even in low-pigmented angles. The aim of the study was to assess the hypotensive effectiveness o...

The development of the chamber angle was studied in the eyes of heterozygous Pax6(lacZ/+) mutant mice (Nature 387 (1997) 406). Mutations in PAX6 cause aniridia, a condition that is frequently associated with glaucoma, a blinding disease that may be associated with chamber angle defects. Mesenchymal cells were seen in the chamber angle at P1-P5. In wild-type mice, these cells differentiated into...