Resistance to chemotherapeutic agents is a major obstacle in cancer treatment. A recently proposed strategy target the collateral sensitivity of multidrug resistant (MDR) cancer. Paradoxically, toxicity certain metal chelating increased, rather than decreased, by function P-glycoprotein (Pgp), which known confer resistance effluxing compounds from cells. We have characterized and compared solut...

iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Although desferrioxamine (DFO) has been available for treating transfusional iron overload from the early 1960s, the era of modern and effective iron chelating therapy started only 20 years ago with the introduction of subcutaneous DFO infusions by portable pumps...

The animal assay of potential new iron-chelating agents is at present dependent on cumbersome and imprecise iron balance studies in hypertransfused rodents. We report the development of a radioisotope assay in intact rats based on the transient labeling by ferritin 59Fe of the main source of chelatable iron within hepatocytes. The isotope was maximally available to chelators during the first 6 ...

Major commercial applications of chelators include the pulp and paper, textile, metal, photographic, cosmetic and detergent industry.The substitution of polyphosphates in P-free washing products with complexing agents such as nitrilotriacetic acid (NTA), sodium citrate, sodium carboxymethyltartonate (CMT) and recently co-polymeric carboxylic acids and inorganic builder Zeolite type A enabled th...

Acinetobacter baumannii is an emerging nosocomial pathogen, responsible for infection outbreaks worldwide. The pathogenicity of this bacterium is mainly due to its multidrug-resistance and ability to form biofilm on abiotic surfaces, which facilitate long-term persistence in the hospital setting. Given the crucial role of iron in A. baumannii nutrition and pathogenicity, iron metabolism has bee...

background: tissue iron deposition may disturb functions of the organs. in many diseases like thalassemia, the patients suffer from iron deposition in kidney and heart tissues. deferoxamine (df) is a synthetic iron chelator and silymarin (sm) is an antioxidant and also a candidate for iron chelating. this study was designed to investigate the effect of df and sm combination against kidney and h...

Cefiderocol (S-649266) is a novel parenteral siderophore cephalosporin conjugated with a catechol moiety at the third-position side chain. The in vitro activity of cefiderocol against Pseudomonas aeruginosa was enhanced under iron-depleted conditions, whereas that of ceftazidime was not affected. The monitoring of [thiazole-14C]cefiderocol revealed the increased intracellular accumulation of ce...

objectives: different chelators may be used during root canal treatment, offering various advantages including lubricant effect inside the canal and smear layer removal. however, chelator residues in narrow root canals can lead to apical microleakage. the aim of this in-vitro study was to compare apical microleakage following the use of three root canal chelators via fluid filtration method in ...

Although it is known that Candida albicans causes endothelial cell injury, in vitro and in vivo, the mechanism by which this process occurs remains unknown. Iron is critical for the induction of injury in many types of host cells. Therefore, we investigated the role of iron in Candida-induced endothelial cell injury. We found that pretreatment of endothelial cells with the iron chelators phenan...