l)e cent (If the wet weight of the organs. In a study of 143 German women, I\’Iischel4 found that the total iron ill the blood and tissue of the placentas averaged 1 l . 1 amid 4.2 mug., respectively, Tier 100 gin. of wet saniple. \Iore inforniation on the iron content of placelltas is needed in the evaluation of the iron requirement during pregnancy. The Inajority of investigations of this pro...

The thorium content of mine dust collected at various locations along the drift to the SNO site has been measured with several techniques-direct counting, proton induced x-ray emission, x-ray fluorescence, and neutron activation analysis. The thorium content varies significantly, from a minimum of 4 ppm to a maximum of 24 ppm (from direct counting measurements). The average Th content of the si...

Iron deficiency is defined as a decreased total iron body content. Iron deficiency anemia occurs when iron deficiency is sufficiently severe to diminish erythropoiesis and cause the development of anemia. Iron deficiency is the most prevalent single deficiency state on a worldwide basis. It is important economically because it diminishes the capability of individuals who are affected to perform...

NF-κB activation induced by lipopolysaccharide (LPS) in cultured hepatic macrophages (HM) may be abrogated by pretreatment of cells with a lipophilic iron chelator, 1,2-dimethyl-3-hydroxypyrid-4-one (L1, deferiprone), suggesting a role for iron in this molecular event [M. Lin, M., R. A. Rippe, O. Niemelä, G. Brittenham, and H. Tsukamoto, Am. J. Physiol. 272 ( Gastrointest. Liver Physiol. 35): G...

Since the first description by Theorell (11) of a process of isolating and purifying myoglobin from horse heart by crystallization, several workers have succeeded in preparing myoglobin by Theorell’s procedure. Roche and Vieil (8) and Rossi and Aragona (9) have described methods less arduous than Theorell’s. Their methods, however, sacrifice yield to gain simplicity. We have developed a modific...

As more data are accumulated it becomes increasingly evident that great variations exist in the mineral content of different samples of the same foodstuff. Only when a large number of samples from different parts of the country have been analyzed will it be possible to approximate the probable mineral content of our diet. With the data now available it is difficult to draw any safe conclusion a...

Measurement of the concentration of iron in the skin, if correlated with total body iron stores, may enable better informed decisions on when to initiate, change or stop therapy in hereditary heamochromatosis. Naïve haemochromatosis patients with iron overload and with C282Y and/or H63D HFE mutations were evaluated at the following time-points: disease diagnosis, end of the therapy programme, a...

One prime feature of alcoholic liver disease (ALD) is iron accumulation in hepatic macrophages/Kupffer cells (KC) associated with enhanced NF-kappaB activation. Our recent work demonstrates a peroxynitrite-mediated transient rise in intracellular labile iron (ILI) as novel signaling for endotoxin-induced IKK and NF-kappaB activation in rodent KC. The present study investigated the mechanism of ...

RATIONALE Because the characteristics of all body fluids depends on patient's health status, is it possible that disadvantaged and socially vulnerable mothers may have lower amounts of iron in their breast milk, and that their babies receive lower content of the mineral for their normal growth and development. Assuring a preventive treatment of the mother might solve this problem. OBJECTIVE T...