Forty infants, 6 to 36 mo old, with iron-deficiency anemia (hemoglobin < 11 g/dL) were matched and assigned to two groups. One group received FeS0(4) and the other received ferrous bis-glycinate chelate at a dose of 5 mg of Fe daily per kilogram of body weight for 28 d. Both groups had significant hemoglobin increases (P < 0.001), but only the group treated with ferrous bis-glycinate chelate ha...

Anemia is an important public health and clinical problem. Observational studies have linked iron deficiency and anemia in children with many poor outcomes, including impaired cognitive development. In this study, we summarize the evidence for the effect of daily iron supplementation on cognitive performance in primary-school-aged children. We searched electronic databases (including MEDLINE an...

sis usually involve chaotropic agents such as guanidinium chloride and (or) detergents for the dissociation of iron at an acidic pH from transferrin. Reduction is achieved with various reducing compounds such as ascorbic acid, hydroxylamine, thioglycolic acid, and others. Among these, ascorbic acid is unique in its property not only to reduce but also to chelate iron. This property appears to b...

This paper discusses the properties of scattering–dominated active galactic nuclei (AGN). We define these to be AGN for which the direct line-of-sight to the continuum source is obscured by Compton-thick material. The aim is to construct, for the first time, a model consistent with X-ray line luminosities, line ratios and various luminosity indicators. The ASCA spectra of six such sources show ...

The dilference between the energy spectra of iron and other cosmic rays is interpreted in terms of two source mechanisms. One mechanism, possibly acceleration at neutron star surfaces, produces the iron, and another is responsible for the rest of the primary nuclei. Within this model, observations of high-energy cosmic rays could determine whether secondary nuclei are produced in the sources or...

The periplasmic iron binding protein of pathogenic Gram-negative bacteria performs an essential role in iron acquisition from transferrin and other iron sources. Structural analysis of this protein from Haemophilus influenzae identified four amino acids that ligand the bound iron: His(9), Glu(57), Tyr(195), and Tyr(196). A phosphate provides an additional ligand, and the presence of a water mol...