The inventory routing problem (IRP) is an integration of vehicle and management problems. In the recent years, it has increasingly drawn attention researchers because its potentially significant practical value. IRP classified as NP-hard since subsumes (VRP). This fact led to development many heuristic or metaheuristic approaches, although a small number exact methods have been introduced recen...

Abstract Resource adequacy (RA) is the ability of an electricity system to reliably satisfy loads using its available resources. Assessing and maintaining RA becoming more challenging due increasing coal plant retirements, penetration wind solar resources, reliance on bilateral market transactions, emerging technologies. evaluation planning have traditionally been conducted by utilities oversee...

An integrated supply chain operational planning system is a tool that is used to jointly optimize several planning decisions by capturing the additional bene ts of coordination between sequential activities in the chain. In recent years, many companies have set up an integrated planning system and achieved multi-million cost savings. The key to success is an application that is not only able to...

Modern electric vehicle heating, ventilation, and air-conditioning (HVAC) systems operate in more efficient heat pump mode, thus, improving the driving range under cold ambient conditions. Coupling those HVAC with novel heating technologies such as infrared panels (IRP) results a complex system multiple actuators, which needs to be optimally coordinated maximise efficiency comfort. The paper pr...

A large-scale computational and genetic analysis study by Nilsson et al. (2009) has identified five genes that coexpress with heme biosynthetic enzymes and are required for normal heme synthesis. Several are implicated in iron-sulfur cluster biogenesis, and malfunction of these genes may repress heme synthesis by activating the IRE/IRP posttranscriptional regulatory system.

Ehrlichia chaffeensis and E. sennetsu are genetically divergent obligatory intracellular bacteria of human monocytes and macrophages, and the human granulocytic ehrlichiosis (HGE) agent is an obligatory intracellular bacterium of granulocytes. Infection with both E. chaffeensis and E. sennetsu, but not HGE agent, in the acute monocytic leukemia cell line THP-1 almost completely inhibited by tre...

Cellular iron levels are closely monitored by iron regulatory and sensor proteins of Mycobacterium tuberculosis for survival inside macrophages. One such class of proteins systematically studied in eukaryotes and reported in a few prokaryotes are the iron-responsive proteins (IRPs). These IRPs bind to iron-responsive elements (IREs) present at untranslated regions (UTRs) of mRNAs and are respon...

A R T I C L E I N F O Lean implementation barriers, machine tool sector, ISM, IRP Received 18 June 2014 Accepted 04 August 2014 Available online 1 December 2014 Acute global competition has forced organization to adopt Lean manufacturing strategy in order to improve competitive potential. Top managements should examine the barriers to lean in order to ensure its effective implementation. This p...

BACKGROUND AND OBJECTIVES The functions of the iron regulatory proteins (IRP1 and IRP2), which control cellular iron homeostasis are similar but not identical. As an inappropriate up-regulation of total IRP activity has been found in the duodenum and monocytes of patients with hereditary hemochromatosis (HH), we investigated the respective roles of IRP1 and IRP2 in these settings. DESIGN AND ...