Land cover is one of basic data layers in geographic information system for physical planning and environmentalmonitoring. Digital image classification is generally performed to produce land cover maps from remote sensing data,particularly for large areas. In the present study the multispectral image from IRS LISS-III image along with ancillary datasuch as vegetation indices, principal componen...

The preparation of vegetation cover maps by used the land inventory and a traditional method has a lot of cost and time. But today, remote sensing is one of the main sources of data collection and information production for study and monitoring land resources, and was efficient tools for providing quickly and timely data and information needs for program planning in the natural resource filed. ...

In vascular smooth muscle cells (VSMCs), platelet-derived growth factor (PDGF) plays a major role in inducing phenotypic switching from contractile to proliferative state. Importantly, VSMC phenotypic switching is also determined by the phosphorylation state/expression levels of insulin receptor substrate (IRS), an intermediary signaling component that is shared by insulin and IGF-I. To date, t...

BACKGROUND Activation of the renin-angiotensin system (RAS) plays a critical role in the pathophysiology of myocardial infarction (MI) and the development of heart failure. Both angiotensin-converting enzyme 2 (ACE2) and insulin/insulin receptor substrate-1 (IRS-1) show cardioprotective effects after acute MI. The Arg972 IRS-1 polymorphism is associated with diminished activity of insulin. In t...

We have previously characterized an insulin receptor substrate 1 (IRS-1)-overexpressing beta-cell line. These beta-cells demonstrated elevated fractional insulin secretion and elevated cytosolic Ca(2+) levels compared with wild-type and vector controls. This effect of IRS-1 may be mediated via an interaction with the sarco-endoplasmic reticulum calcium ATPase (SERCA). Here we demonstrate that I...

Insulin receptor substrate (IRS) molecules are key mediators in insulin signaling and play a central role in maintaining basic cellular functions such as growth, survival, and metabolism. They act as docking proteins between the insulin receptor and a complex network of intracellular signaling molecules containing Src homology 2 (SH2) domains. Four members (IRS-1, IRS-2, IRS-3, IRS-4) of this f...

D-glucose regulates maintenance and function of pancreatic beta-cells. Several studies have shown that IRS-2, but not IRS-1, is necessary to maintain and sufficient to expand functional beta-cell mass. We therefore analyzed the expression of IRS-2 and IRS-1 in beta-cells after culture in the presence of various concentrations of D-glucose and other metabolisable or non-metabolisable hexoses. D-...

soil salinity has been a large problem in arid and semi arid regions. preparation of such maps is useful for natural resource managers. old methods of preparing such maps require a lot of time and cost. multi-spectral remotely sensed dates due to the broad vision and repeating of these imageries is suitable for provide saline soil maps. this investigation is conducted to provide saline soil map...