Due to fast growth of portable devices, power consumption and timing delays are the two important design parameters in high speed and low power VLSI design arena. In this paper we presents the comparison of single edge triggered static D flip-flop designs to show the benefit of power consumption ,delay and power delay product on the basis of area efficiency.

This paper presents low power clock gating adiabatic D flip-flop using single phase sinusoidal power clock scheme. We propose the clock gated single phase Quasi-Static Energy Recovery Logic (QSERL) D flip-flop at 90nm CMOS technology. In the previously proposed QSERL logic, two phase sinusoidal power clocks were used that increased the hardware complexity and clocking issues. In this paper, sin...

Combination treatment regimens that include topoisomerase-II-targeted drugs, such as doxorubicin, are widely used in the treatment of breast cancer. Previously, we showed that IFN-gamma and doxorubicin cotreatment synergistically induced apoptosis in MDA435 breast cancer cells in a signal transducer and activator of transcription 1-dependent manner. In this study, we found that this synergy was...

The power consumption of the clock tree dominates over 40% of the total power in high performance VLSI designs. Hence, low power clocking schemes are promising approaches for low power design. We propose energy recovery clocked flip-flops that enable energy recovery from the clock network, resulting in significant energy savings. These flip-flops operate with a single-phase sinusoidal clock whi...

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to induce apoptosis in a variety of tumorigenic and transformed cell lines but not in many normal cells. Hence, TRAIL has the potential to be an ideal cancer therapeutic agent with minimal cytotoxicity. FLICE inhibitory protein (c-FLIP) is an important regulator of TRAIL-induced apoptosis. Here, we show that persiste...

Death receptor activation triggers recruitment of FADD, which via its death effector domain (DED) engages the DEDs of procaspase 8 and its inhibitor FLIP to form death-inducing signalling complexes (DISCs). The DEDs of FADD, FLIP and procaspase 8 interact with one another using two binding surfaces defined by α1/α4 and α2/α5 helices, respectively. Here we report that FLIP has preferential affin...

− This paper describes novel low-power high-speed flip-flop called dual edge-triggered NAND keeper flip-flop (DETNKFF). The flip-flop achieves substantial power reduction by incorporating dual edge-triggered operation and by eliminating redundant transitions. It also minimizes the data-tooutput latency by reducing the height of transistor stack on the critical path. Moreover, DETNKFF allows neg...

Flip-Flop_1: Firstly, the old flip-flop construction that we choose to implement is the classic single edge triggered flip-flop (SETFF) which is shown in FIGURE 10.24 in the book " CMOS VLSI Design A Circuits and Systems Perspective " 4th Edition. The figure is shown below. Fig A-1 Resettable Flip-Flop The schematic that we construct is shown as follows: Fig A-2 Resettable Flip-Flop Schematic T...

Cellular FLIP (c-FLIP), also known as FLICE-inhibitory protein, has been identified as an inhibitor of apoptosis triggered by engagement of death receptors (DRs) such as Fas or TRAIL (TNF-related apoptosis-inducing ligand). cFLIP is recruited to DR signalling complexes, where it prevents caspase activation. Animal models have indicated that c-FLIP plays an important role in T cell proliferation...

Cellular FLICE-like inhibitory protein (c-FLIP) is an inhibitor of death receptor-mediated apoptosis and exerts its anti-apoptotic function by blocking the activation of caspase-8. We recently showed that the siRNA-mediated knockdown of c-FLIP in MCF-7 breast cancer cells growing in vitro triggered apoptosis. The aim of this study was to determine if the in vivo knockdown of c-FLIP in MCF-7 bre...