Isatin , w hich is the su b stra te fo r industria l syn­ thesis o f the m ost p o p u la r fabric dye, the indigo, has been sub ject to elec tro ly tic red u c tio n u n d e r a varie ty of experim en ta l cond itions [1,2]. P o laro ­ graphie b ehav io r o f isatin and a varie ty of isatin derivatives has been described in m any of papers [3 -6 ] , H ow ever, m ost o f those rep o rts w ere d...

Nowadays, cancer is one of the main reasons of death between nations caused by different elements such as presence of mutagenic and cancer causing materials in the environment. Isatin and Carbon nanotubes can be used to deliver their cargoes to cells and organs. The potential use of them to treat several types of cancer, with minimal or no toxic effects to normal cells. In the present study, 1,...

In the present work, some new 5-[2(3)-dialkylamino alkoxy] Indole 2, 3-diones were prepared from 5-hydroxy isatin. A mixture of 5-hydroxy isatin, dialkylamino alkylhalide in alcoholic potassium hydroxide was stirred at room temperature for 6 hours to get the 5-[2(3)dialkylamino alkoxy] Indole 2,3-diones. The structures of the products were characterized by IR, NMR, MASS Spectral studies. All th...

In the title compound, C(16)H(13)ClN(4)OS, the isatin ring system is oriented at dihedral angles of 10.60 (7) and 72.60 (3)° with respect to the thio-semicarbazide and 2-chloro-benzyl groups, respectively. The near planarity of the isatin and thio-semicarbazide groups [r.m.s. deviations of 0.0420 and 0.0163 Å, respectively] is reinforced by intra-molecular N-H⋯O and N-H⋯N hydrogen bonds, which ...

The aim of the present study is to synthesize the oxovanadium complex of the V3+ ion with isatin sciff bases. Spectroscopic methods have been used to confirm these models of complexation and to understand the structures of the species formed in methanolic solution. We also have isolated a complex of Vanadium (III) with isatin schiff bases in the solid phase.

We have recently identified a new class of compounds that selectively kill cells that express P-glycoprotein (P-gp, MDR1), the ATPase efflux pump that confers multidrug resistance on cancer cells. Several isatin-beta-thiosemicarbazones from our initial study have been validated and a range of analogues synthesized and tested. A number demonstrated improved MDR1-selective activity over the lead,...

The inhibition of corrosion of mild steel in hydrochloric acid by isatin glycine (ING) and isatin (IN) at 30-60 o C and concentrations of 0.0001 M to 0.0005 M was studied via weight loss method. At the highest inhibitor concentration studied ING exhibited inhibition efficiency of 87% while IN exhibited 84% at 60 o C. A chemical adsorption mechanism was proposed on the basis of the temperature e...

Some new isatin3hydrazone derivatives that are Isatin3(benzylidene)hydrazone, Isatin3-(methyl ethylide)hydrazone, isatin 3-(isoproplylidene)hydrazone have been synthesized from the reaction of isatin3-hydrazone and different aldehydes and ketones. Thestructure of synthesized compound is assigned on the basis of, IR, 1HNMR, 13CNMRdata. The anti microbial activity was done by disk diffusion metho...

the interaction between isatin-β-thiosemicarbazone (ibt) and calf thymus dna (ct-dna) was investigated in physiological buffer (ph 7.4) using neutral red (nr) dye as a spectral probe by uv–vis absorption and fluorescence spectroscopy, as well as viscosity measurements. the ibt is stabilized by intercalation in the dna ( k [ibt –dna] =1.03×105 m−1), and displaces the nr dye from the nr–dna comple...