The pseudospectral abscissa and the stability radius are well-established tools for quantifying the stability of a matrix under unstructured perturbations. Based on first-order eigenvalue expansions, Guglielmi and Overton [SIAM J. Matrix Anal. Appl., 32 (2011), pp. 1166-1192] recently proposed a linearly converging iterative method for computing the pseudospectral abscissa. In this paper, we pr...

Philip Bourne (Fig 1) began his scientific career in the wet lab, like many of his computational biology contemporaries. He earned his PhD in physical chemistry from the Flinders University of South Australia and pursued postdoctoral training at the University of Sheffield, where he began studying protein structure. Bourne accepted his first academic position in 1995 in the Department of Pharma...

tute, a platform of Genoma España, www.inab.org). The meeting is affiliated to the International Society for Computational Biology (ISCB). Both INB and ISCB, together with the Spanish Bioinform-atics Network, the BioSapiens Network and the Steering Committee of the ECCB have played a key role in the promotion, organization and continuity of this international event. The ECCB series was founded ...

S the titIe of this contribution A indicates, the subject has at Ieast three major aspects: the medical (dermatologic), the forensic, and the industria1 or economic. It is obviously impossibIe to do justice to al1 three in this relativeIy brief communication. For the discussion of the IegaI aspect aIone wouId require a voIuminous treatise, as each country, and, in the United States, each State,...

This short report summarises the scientific content and activities of a student-led event, the 1st student symposium by the UK Regional Student Group of the International Society for Computational Biology. The event took place on the 8th of October 2014.

The 23rd Annual International Conference on Intelligent Systems for Molecular Biology and the 14th European Conference on Computational Biology (ISMB/ECCB 2015) is shaping up to be a phenomenal meeting, with world-renowned keynote speakers and changes in the meeting format that aim to make it a more streamlined and user-friendly conference. The joint ISMB/ ECCB conference is held biennially and...

We develop the Q method for the Second Order Cone Programming problem. The algorithm is the adaptation of the Q method for semidefinite programming originally developed by Alizadeh, Haeberly and Overton, [3] and [2]. We take advantage of the special algebraic structure associated with second order cone programs to formulate the Q method. Furthermore we prove that our algorithm is globally conve...

The Hodgkin-Huxley model of nerve pulse propagation relies on ion currents through specific resistors called ion channels. We discuss a number of classical thermodynamic findings on nerves that are not contained in this classical theory. Particularly striking is the finding of reversible heat changes, thickness and phase changes of the membrane during the action potential. Data on various nerve...

We discuss several different search directions which can be used in primal-dual interior-point methods for semidefinite programming problems and investigate their theoretical properties, including scale invariance, primal-dual symmetry, and whether they always generate well-defined directions. Among the directions satisfying all but at most two of these desirable properties are the Alizadeh-Hae...