BACKGROUND/AIMS Licorice has been used to treat many diseases, including palpitations, in both Eastern and Western societies for thousands of years. It has been reported that glycyrrhetinic acid (GA), an aglycone saponin extracted from licorice root, exerts protective effects on the cardiovascular system, limits infarct sizes and protects against the development of arrhythmia. However, the mech...

Objective(s): The aim of the present study is to investigate probable acute effects of vitamin D on ischemia-reperfusion injury in the rat ovary.Materials and Methods: A group of 30 Wistar albino rats was divided into five groups of 6 each. Group 1:  underwent laparotomy only and the ovaries were removed. Group 2:  3-hr ischemia followed by excision of the ovaries. Group 3:  3-hr ischemia and 3...

Background & Target: Ischemia Reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. In this study, the effect of pentoxyfylline on bcl2 gene expression changes and cell injury in kidney of rat following Ischemia Reperfusion were evaluated.Methods: In this experimental study, 20 male wistar rats with average weight of...

introduction: during kidney and other organ's transplantation, the organ to be transplanted, must inevitably remain out of the body with little or no blood perfusion at all, for long period of time (ischemia). this causes the release of oxygen free radicals (ofr). reperfusion (reintroduction of blood flow) will further exacerbate the initial damage caused by the ischemic insult and may result i...

BACKGROUND The present study was to investigate the effects and mechanism of Luteolin on myocardial infarct size, cardiac function and cardiomyocyte apoptosis in diabetic rats with myocardial ischemia/reperfusion (I/R) injury. METHODOLOGY/PRINCIPAL FINDINGS Diabetic rats underwent 30 minutes of ischemia followed by 3 h of reperfusion. Animals were pretreated with or without Luteolin before co...

Background: The aim was to investigate the antioxidant effects of lycopene and caffeine in rats exposed renal ischemia/reperfusion injury. Materials Methods: Following right nephrectomy, 60 minutes ischemia followed by reperfusion were performed 200-250 gram Wistar albino used study. 30 before ischemia, (5 mg/kg), (50 mg/kg) + administered intraperitoneally rats. After experiment, 4 ml blood le...

Introduction: Stroke is the third important reason of death in adults and an important cause of adult disability. Previous studies suggest that TGF-alpha can induce neurogenesis after stroke. Here in, we studied neurogenesis effects of the TGF-alpha on subventricular zone following ischemia-reperfusion. Male wistar rats (250-300 g) were divided into ischemia and treatment groups. After inductio...

Background: Cerebral ischemia/ reperfusion leads to programmed cell death or planned apoptosis. Hippocampus is a very sensitive tissue cerebral ischemia. Propofol an anesthesia that recently the use of this drug as neuroprotective has been considered. In study, effect propofol on CA2 and CA3 areas hippocampus following ischemia was investigated.

The purpose of the present study was to determine whether Na(+)-H+ and Na(+)-Ca2+ exchanges modulate postischemic recovery of excitation-contraction coupling. Experiments were performed in 43 isolated isovolumic dog hearts perfused with blood (pH 7.40, 141 mmol/L Na+, 34 degrees C, paced at 2 Hz). A 3 x 3-mm region at the left ventricular (LV) apex was loaded with aequorin for monitoring [Ca2+]...