The maturational stage of the brain at the time of injury plays a key role in the pattern of brain damage in humans, including regional and cell-type–specific susceptibility. In this minireview, we will summarize available models of preterm and at-term ischemic brain injury in rodents and in larger species and discuss how maturation stage of the brain at the time of an insult affects the underl...

Ischemic stroke remains the predominant cause of disability in population (3.2 per 1000 population). Only 8% ischemic survivors can return to their previous work. Nutritional support is an integral part multidisciplinary approach treatment intensive care unit during acute and rehabilitation phases. Brain damage always has metabolic consequences on patients body, premorbid malnutrition stroke-st...

This study was carried out with a recently developed model of focal cerebral ischemia in the rat based on the photochemical induction of thrombotic stroke using the dye Rose Bengal. We examined the change in the volume of the lesion and brain water content, in separate groups of rats, at different times (1, 4, 24, 72, and 168 h) after the induction of the ischemic lesion. The volume of ischemic...

Oxidative stress is the common underlying mechanism of damage in ischemic stroke. Therefore, we aimed to evaluate the possible protective effects of polyhydroxylated fullerene derivatives on brain infarction and oxidative/nitrosative stress in a rat model of ischemic stroke. The experiment was performed by four groups of rats (each; n=12); Sham, Control ischemia, and ischemic treatment groups (...

BACKGROUND AND PURPOSE We investigated the effect of temporary treatment with a nonhypotensive dose of valsartan on ischemic brain damage in C57BL/6 mice. METHODS We separated the mice into 3 groups of valsartan treatment before middle cerebral artery (MCA) occlusion: (1) for 4 weeks: Val (2W, 2W); (2) for 2 weeks followed by its cessation for 2 weeks: Val (2W, -); and (3) no treatment for 4 ...

background & objectives: ischemic stroke is the third leading cause of death and disability in most of the human societies. there is no effective treatment due to complexity of the pathophysiological mechanisms. today, more researches are designed to introduce involving factors and new treatment strategies in brain ischemia. the objective of this study is to introduce an experimental model of t...

The hypothesis that arterial hypotension aggravates hypoglycemic brain damage was tested. Thirty minutes of insulin induced hypoglycemia with a flat EEG ("isoelectricity") was compared in seven series of rats. In three series of animals, the energy state of the cerebral cortex was determined at blood pressures of 140, 100 and 80 mm Hg respectively. Hypotension during hypoglycemia exacerbated co...

OBJECTIVE Age and excessive energy intake/obesity are risk factors for cerebrovascular disease, but it is not known if and how these factors affect the extent of brain damage and outcome in ischemic stroke. We therefore determined the interactions of age and energy intake on the outcome of ischemic brain injury, and elucidated the underlying mechanisms. METHODS We utilized a novel microchip-b...

Ischemic brain damage can be prevented or at least significantly reduced when there is a preceding brief ischemic period that does not exceed the threshold for tissue damage--a phenomenon termed "ischemic preconditioning" (ischemic PC). Experimental PC in rodents is now considered to be a model for transient ischemic attacks in humans, and there is increasing hope for translating the knowledge ...

BACKGROUND AND PURPOSE We examined the possibility that activation of the human brain renin-angiotensin system is involved in enhancement of ischemic brain damage using chimeric transgenic mice with human renin (hRN) and human angiotensinogen (hANG) genes. METHODS Chimeric (hRN/hANG-Tg) mice were generated by mating of hRN and hANG transgenic mice. Permanent occlusion of the middle cerebral a...