The first in vivo magnetic resonance study of experimental cerebral malaria is presented. Cerebral involvement is a lethal complication of malaria. To explore the brain of susceptible mice infected with Plasmodium berghei ANKA, multimodal magnetic resonance techniques were applied (imaging, diffusion, perfusion, angiography, spectroscopy). They reveal vascular damage including blood-brain barri...

BACKGROUND AND PURPOSE The ischemic edema associated with blood-brain barrier permeability changes and the excess production of free radicals are serious complications in prolonged cerebral ischemia. We examined the efficacy of transvenous perfusion of the brain, starting treatment 5 hours after occlusion of the middle cerebral artery for a period of 2 hours in rats with the combined agents man...

Intracranial Hypertension Following Aneurysmal Subarachnoid Hemorrhage. In the acute phase after aneurysmal subarachnoid hemorrhage, secondary brain injuries including posthemorrhagic hydrocephalus, repeat hemorrhage, brain edema, and vasospasmrelated ischemic strokes can lead to intractable intracranial hypertension that can be life-threatening in cases of severely compromised cerebral

BACKGROUND AND PURPOSE Red blood cell (RBC) lysis contributes to brain edema formation after intracerebral hemorrhage (ICH), and RBC hemolysate (oxyhemoglobin) has been implicated to be a spasminogen in subarachnoid hemorrhage. Whether cerebral ischemia contributes to brain edema formation after ICH remains unclear, however. The aims of this study were to test whether extravasation of RBCs indu...

CEREBRAL EDEMA IS A SIGNIFICANT cause of mortality in patients with traumatic brain injury and ischemic or hemorrhagic stroke. Yet our understanding of the cellular and molecular mechanisms underlying this condition is rather limited, and new treatments showing promise in laboratory studies have frequently been found ineffective in clinical practice. Two types of edema, namely vasogenic and cel...

An alteration of the blood-brain barrier (BBB) permeability contributes to the development of brain edema after stroke. In this study, we evaluated the effects of 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a novel calmodulin antagonist, on brain edema formation and BBB integrity in rats subjecte...

Background and Objective: The S100B protein has recently been considered as an important marker for predicting severe brain damage; however there has been very little evidence of increasing this marker in cerebral edema due to metabolic disorders such as diabetes ketoacidosis (DKA). This study was designed and performed to evaluate the prognostic role of S100B protein in predicting brain edema ...