نتایج جستجو برای: iso effective dose
تعداد نتایج: 978523 فیلتر نتایج به سال:
This paper outlines some key elements of quality system standards ISO 9000 and their application to Information Technology and software development. Emphasis is put on the need for closed feedback loops in the organization which will provide a stable framework for effective quality management. Application of the generic ISO 9000 standards to software development has to take into account the spe...
Numerous clinical therapeutic agents have been identified as DNA damaging. The present study revealed that isoproterenol (Iso) resulted in DNA damage in vascular smooth muscle cells (VSMCs) and increased the levels of intracellular oxygen free radicals. Administration of chlorogenic acid (CGA) inhibited this effect. Pretreatment with CGA abrogated the increase in protein expression levels of γ‑...
The use of forklifts to move material is very common in large manufacturing companies. Exposure to whole body vibration from industrial vehicles such as forklifts has been associated with low back pain and also with the degeneration of intervertebral disc. Predicted health risks, associated with the operation of forklifts, based on ISO 2631-1 criteria are limited and have not yet been determine...
We examined the effects of several E-ring and F-ring isoprostanes on mechanical and electrophysiological activity in porcine coronary artery. Several isoprostanes evoked concentration-dependent contractions, with 8-iso-PGE2 being the most potent (-log EC50 of 6.9 +/- 0.1); this excitatory effect has been described in detail elsewhere and was not examined further here. 8-iso-PGE2 evoked dose-dep...
The radiation killing of tumor cells by ionizing radiation is best described by the linear-quadratic (LQ) model. Research into the underlying mechanisms of α- and β-inactivation has suggested that different molecular targets (DNA in different forms) and different microdosimetric energy deposits (spurs versus electron track-ends) are involved. Clinical protocols with fractionated doses of about ...
Isoprenaline (ISO) at high doses can cause severe stress to myocardium resulting in an infarct-like necrosis rats. However, its effects repeatedly low dose exposure on heart, kidney and aorta are still unclear. Hence, this study was aimed investigate the of repeated administration ISO organs rats by using Langendorff-perfused isolated hearts, ELISA kits, qPCR histopathology techniques. Male Wis...
PURPOSE To determine the cholinergic (carbachol, CCH) and adrenergic (norepinephrine, NE) modulation of Ca2+ response to endothelin-1 in human ciliary smooth muscle (HCSM) cells. METHODS Intracellular calcium levels were measured using the Fura-2 calcium imaging system in HCSM cells treated either singly with endothelin-1 (ET-1; 2-200 nM), CCH (1-100 microM), NE (0.1-10 microM) or isoproteren...
The current investigation was proposed to assess the effectiveness of combination resveratrol and ascorbic acid against Isoproterenol (ISO)-induced myocardial infarction in rats. experimental model divided into six groups (n = 6 each group). Group I: control, 2: isoproterenol (ISO)-100 mg/kg b.wt, 3: ISO+Resveratrol (RES) (20 b.wt) treated, 4: ISO+ Ascorbic (AA) (80 5: ISO+RES b.wt)+AA treated ...
BACKGROUND β1-2-adrenergic receptors (AR) are key regulators of cardiac contractility and remodeling in response to catecholamines. β3-AR expression is enhanced in diseased human myocardium, but its impact on remodeling is unknown. METHODS AND RESULTS Mice with cardiac myocyte-specific expression of human β3-AR (β3-TG) and wild-type (WT) littermates were used to compare myocardial remodeling ...
BACKGROUND Our objectives were to characterize functional and structural features of an experimental model of Takotsubo cardiomyopathy, and its response to beta-blockers. METHODS AND RESULTS In protocol 1, a dose-finding study: 69 rats received various doses of isoproterenol (ISO) and echocardiographic and histologic parameters were measured on days 2 to 3 or day 8. There were no dose-depende...
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