the sequestration of rat leukocytes and bone marrow cells by the lung vasculature was studied using an isolated perfused rat lung preparation. the passage of latex particles of 7.6 µm in diameter and non-hematopoietic cells through the lung blood vessels was also studied. leukocytes and bone marrow cells were reversibly sequestered from circulation, whereas, latex particles and non-hematopoieti...

The carbohydrate metabolism of isolated rat liver parenchymal cells was investigated. Cells isolated from fed rats retained glycogen and released glucose into the suspending medium at a rate of about 25 pg of glucose per mg of cell protein per hour. Glucagon, epinephrine, or cyclic nucleotides stimulated glycogenolysis about 220 to 250%. Cells isolated from rats fasted 18 to 24 hours synthesize...

The effect of thyroid-hormone application on cytosolic and mitochondrial ATP/ADP ratio was investigated in rat liver in vivo and in the isolated perfused organ. In vivo the ATP/ADP ratio in livers from hypothyroid rats was 0.84 +/- 0.08 in the mitochondrial matrix and 5.6 +/- 0.9 in the cytosol, as was observed in euthyroid controls. In contrast, hyperthyroidism was followed by a significant de...

The sequestration of rat leukocytes and bone marrow cells by the lung vasculature was studied using an isolated perfused rat lung preparation. The passage of latex particles of 7.6 µm in diameter and non-hematopoietic cells through the lung blood vessels was also studied. Leukocytes and bone marrow cells were reversibly sequestered from circulation, whereas, latex particles and non-hematop...

Stent implantation into aortocoronary saphenous vein grafts (SVG) releases particulate debris and soluble vasoactive mediators, for example, serotonin. We now analyzed effects of the soluble mediators released into the coronary arterial blood during stent implantation on vasomotion of isolated rat epicardial coronary artery segments and on coronary flow and left ventricular developed pressure i...