In the course of our continuing search for novel antimicrobial agents,1-4) we have isolated a novel diketopiperazine, Sch 725418 (1), from culture Micromonospora sp. In this paper, we describe the isolation and structure elucidation of 1 using high resolution ESI-MS and extensive NMR spectroscopic analysis. Fermentation studies of the SP culture 94-00889 were carried out in shake flasks. Stock ...

A macrolide compound known as pandangolide 1 was isolated from fungus Lambertella brunneola. The compound was purified using SiO2 column chromatography while the elucidation of its planar structure was based on the analyses of Nuclear Magnetic Resonance (NMR) spectroscopic data and Mass Spectroscopy (MS). Antifungal assay disclosed that pandangolide 1 weakly showed hyphal growth inhibition agai...

Elaiophylin (1) was isolated in 1959 by Arcamone and co-workers from cultures of Streptomyces melanosporus.1 Subsequently, this natural product has also been obtained from other strains of Streptomyces.2 Structure elucidation of 1, including assignment of absolute stereochemistry, was based on chemical degradation,3 NMR studies,4 and ultimately X-ray crystallographic analysis.5 Isolation and ch...

The phytochemical analysis of the fresh aerial parts of Portulaca oleracea (Portulacaceae), growing in Jordan, using conventional chromatographic procedures resulted in the isolation of Beta-sitosterol, Beta-sitosterol-glucoside, N,N'-dicyclohexylurea, and allantoin. The last three compounds were isolated for the first time from this plant. The structure elucidation of these compounds was attai...

While investigating the cytotoxic activity of the methanol extract of an Australian marine sponge Stelletta sp. (Demospongiae), a new diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine) (1), was isolated together with the known bengamides; A (2), F (3), N (4), Y (5), and bengazoles; Z (6), C(4) (7) and C(6) (8). The isolation and structure elucidation of the diketopiperazine (1), toget...

Several biologically active keto-epoxides, containing a unique decalone with a spiro-ketal linkage through a naphthalene moiety, have been isolated from various fungi.1 ~ 7) In the course of our continuing search for new antitumor agents, two novel minor metabolites, Sch 50673 (1) and Sch 50676 (2) were discovered from the fungus, Nattrassia mangiferae (ATCC74078), in a large scale fermentation...