3364 The Journal of Clinical Investigation http://www.jci.org Volume 121 Number 9 September 2011 For Huda Zoghbi, collaboration is the key to unlocking the secrets of neurobiology In June, the Peter and Patricia Gruber Foundation awarded the 2011 Neuroscience Prize to Huda Zoghbi in recognition of her work uncovering the genetic and molecular causes of neurological disorders. Zoghbi, a professo...

ABSTRAK
 Pendekatan regresi nonparametrik Kernel digunakan untuk memperkirakan harapan bersyarat dari variabel dependen terhadap independen tanpa mengasumsikan bentuk parametrik tertentu. ini menggunakan fungsi sebagai alat melakukan estimasi. Dalam penelitian ini, Gaussian dan estimator Nadaraya-Watson. Estimator Nadaraya-Watson adalah metode yang mengestimasi rata-rata tertimbang secara ...

This research aims to examine the influence determine effect of Singapore interest rates on Jakarta Composite Index (JCI) in banking sector. is a quantitative research. The data were collected using documentation. In order achieve goal study, this study was conducted by type proportional sampling method so that as many 36 samples obtained.The result showed rate (SIBOR) had significant positive ...

Twenty years after the discovery of the vascular endothelial Tie receptor tyrosine kinases and 15 years after the discovery of the Tie2 ligand, angiopoietin-1 (Angpt1, also known as Ang1), a study published in the current issue of the JCI reveals an unexpected loss-of-function phenotype of mice conditionally deleted of the Angpt1 gene. The results suggest that Angpt1 is needed as a vascular sta...

Cardiovascular disease is the leading cause of morbidity and mortality in Western countries. Previous studies have highlighted the beneficial effects of PPARgamma activators on cardiovascular disease; however, the role of other PPAR family members in atherosclerosis is less clear. A report in this issue of the JCI expands our understanding of PPARs in vascular biology and highlights the potenti...

The immune system's battle against pathogens includes the "respiratory burst," a rapid release of ROS from leukocytes, thought to play a role in destroying the invading species. In this issue of the JCI, Paiva et al. demonstrate that oxidative stress actually enhances infection with the protozoan Trypanosoma cruzi, by a mechanism that may involve facilitating parasite access to iron. Their find...

The distal nephron is composed of two main cell types: principal cells and intercalated cells. These cells have distinct morphologic features that allow them to be readily distinguished by light microscopy, as well as distinct suites of proteins that facilitate cell-specific transport properties. In this issue of the JCI, Gueutin and colleagues describe a new mechanism by which β-intercalated c...

Skin cancer cells with donor genotype have been identified in allogeneic transplant patients; however, the donor contribution to the recipient's epithelial malignancy remains to be established. In this issue of the JCI, Verneuil et al. provide the first evidence for donor contribution to the malignant epithelium of skin squamous cell carcinoma in a kidney transplant recipient. This case report ...

Several Bcl-2 family members, including Bim, may contribute to programmed cell death by inducing mitochondrial cytochrome c release, which activates caspase-9 and then caspase-3, the "executioner" of the cell. In this issue of the JCI, Shinoda and collaborators show the key role of Bim in epileptic seizure-induced neuronal injury and identify the contribution of transcription factors responsibl...