Gout is a very painful arthritis that affects millions of people around the world. In the last decade, various mechanisms associated to uric acid crystals-induced joint inflammation have been described, including details related to the activation of the cytoplasmic sensor NLRP3 inflammasome that eventually leads to the maturation and release the cytokine IL-1β. The identification of these signa...

Introduction: Apoptosis dysregulation plays a substantial role in the pathophysiology of chronic inflammation and its related symptoms such as edema. Regulation of NF-ĸB activation is involved in apoptosis pattern change. The current study aimed at verifying the effects of local inflammation on edema and changes in apoptotic markers, and investigating the possible role of NF-ĸB in apoptosis pat...

Background Joint cartilage degradation is resulted by ensuing chronic inflammation in juvenile idiopathic arthritis (JIA). Since the primary goals of treatment are to prevent joint destruction sensitive methods are needed to evaluate cartilage thickness (CTh). Ultrasonography (US) is a reliable tool in the assessment of joint cartilage in rheumatic disease. Previously, we have shown that CTh, i...

the manubrio-sternal and sternoclavicular joints possess synovium,3'4 extension of synovial disease from adjacent costochondral joints, degenerative processes or trauma. Histological and microradiographic analysis has indicated active inflammation of the articulation in some patients and the absence of inflammation and presence offibrous replacement in others.5 Pathological problems with clinic...

When a total dose infusion of iron dextran is given to anaemic rheumatoid patients an exacerbation of inflammatory synovitis in previously affected joints is observed. The adjuvant arthritis model of inflammation in rats has been used to investigate the mechanism of iron promoted synovitis. Either iron dextran (5 mg injected intravenously) with a dextran C control, or iron sorbitol (7.5 mg inje...

Destruction of bone tissue by osteoclasts represents a severe pathological phenotype during inflammatory arthritis and results in joint pain and bone malformations. Previous studies have established the essential role of cytokines including TNFα and receptor-ligand interactions, such as the receptor activator of nuclear factor-kappa B-receptor activator of nuclear factor-kappa B ligand interact...

Although the cyclooxygenase metabolites PGs are known to be involved in the progression of arthritis, the role of PGD2 remains unclear. In this study, we evaluated the contribution of signaling mediated through a PGD2 receptor, chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2), in the progression of adjuvant-induced joint inflammation. Injection of CFA into the ankle j...