The problem of dynamic prediction with time-dependent covariates, given by biomarkers, repeatedly measured over time, has received much attention the last decades. Two contrasting approaches have become in widespread use. first is joint modelling, which attempts to jointly model longitudinal markers and event time. second landmarking, a more pragmatic approach that avoids modelling marker proce...

The assessment of pain is of critical importance for mechanistic studies as well as for the validation of drug targets. This review will focus on knee joint pain associated with arthritis. Different animal models have been developed for the study of knee joint arthritis. Behavioral tests in animal models of knee joint arthritis typically measure knee joint pain rather indirectly. In recent year...

In psoriatic arthritis, permanent joint damage characterizes disease progression and represents a major debilitating aspect of the disease. Understanding the process of joint damage will assist in the treatment and disease management of patients. Multistate models provide a means to examine patterns of disease, such as symmetric joint damage. Additionally, the link between damage and the dynami...

Infants imitate others' individual actions, but do they also replicate others' joint activities? To examine whether observing joint action influences infants' initiation of joint action, forty-eight 18-month-old infants observed object demonstrations by 2 models acting together (joint action), 2 models acting individually (individual action), or 1 model acting alone (solitary action). Infants' ...

disability in the world. One approach to the study of the disease has been through animal models. “Quick models” are used to answer disease-specific questions and study surrogate markers of joint disease, but may not manifest all aspects of the disease process. Actual disease models include mechanical destabilization of the joint or animal models in which OA is a spontaneously occurring disease...

5 Indices for discrete models 6 5.1 Enumeration of joint actions and observations . . . . . . . . . . . 7 5.2 Enumeration of (joint) histories . . . . . . . . . . . . . . . . . . . 7 5.2.1 Observation histories . . . . . . . . . . . . . . . . . . . . . 7 5.2.2 Action histories . . . . . . . . . . . . . . . . . . . . . . . 9 5.2.3 Action-observation histories . . . . . . . . . . . . . . . . . 9 ...

In this paper, we use a novel duration model to study joint retirement in married couples using the Health and Retirement Study. Whereas conventionally used models cannot account for joint retirement, our model admits joint retirement with positive probability and nests the traditional proportional hazards model. In contrast to other statistical models for simultaneous durations, it is based on...