نتایج جستجو برای: kashan erg
تعداد نتایج: 8520 فیلتر نتایج به سال:
We investigated the subthreshold properties of an erg (ether-à-go-go-related gene) K(+) current in Purkinje cells of neonatal mice. Action potentials recorded from Purkinje cells in cerebellar slices exhibited a decreased threshold potential and increased frequency of spontaneous and repetitive activity following application of the specific erg channel blocker E-4031. Accommodation was absent b...
in order to identify the effects of vitamin a and aspirin on reducing uv lightinduced retinopathy, erg waves were compared before and after uv light exposure in rabbits. 30 rabbits were divided into 3 groups: the first group received vitamin a, 50,000 units i.m., single dose, the second group received aspirin, 50 mg/ kg/day po and the third group did not receive any medication. all three groups...
Purpose: We aimed to analyze whether ERG rearrangement in biopsies could be used to assess subsequent cancer diagnosis in high-grade prostatic intraepithelial neoplasia (HGPIN) and the risk of lymph node metastasis in early prostate cancer. Experimental Design: Samples from 523 patients (361with early prostate cancer and 162withHGPIN) were collected prospectively. On the basis of the cutoff val...
Exposure to genotoxic agents, such as ionizing radiation (IR), produces DNA damage, leading to DNA double-strand breaks (DSB); IR toxicity is augmented when the DNA repair is impaired. We reported that radiosensitization by a PARP inhibitor (PARPi) was highly prominent in prostate cancer cells expressing the TMPRSS2-ERG gene fusion protein. Here, we show that TMPRSS2-ERG blocks nonhomologous en...
background: the objective of the study is examining the microbial quality of drinking water in kashan’s villages, and determining the usage of safe water in rural population in terms of microbial quality in the second-half 2007. also the role of kashan rural water and wastewater company (krwwc) in improving drinking water quality in kashan rural areas was investigated. methods: in this descript...
Notch and Angiopoietin-1 (Ang1)/Tie2 pathways are crucial for vascular maturation and stability. Here we identify the transcription factor ERG as a key regulator of endothelial Notch signalling. We show that ERG controls the balance between Notch ligands by driving Delta-like ligand 4 (Dll4) while repressing Jagged1 (Jag1) expression. In vivo, this regulation occurs selectively in the maturing ...
The TMPRSS2:ERG gene fusion is common in androgen receptor (AR) positive prostate cancers, yet its function remains poorly understood. From a screen for functionally relevant ERG interactors, we identify the arginine methyltransferase PRMT5. ERG recruits PRMT5 to AR-target genes, where PRMT5 methylates AR on arginine 761. This attenuates AR recruitment and transcription of genes expressed in di...
.raditional studies of the animal and human electroretinogram (ERG) indicate that the stimulus intensity necessary to evoke a minimal ERG from the dark adapted retina is well above the absolute threshold of vision; these studies also show that the ERG response at threshold consists of the b-wave only, and the a-wave appears at suprathreshold intensities. Recent work on the toad, rat, cat, monke...
Mammalian Ether-a-go-go related gene (Erg) family voltage-gated K(+) channels possess an unusual gating phenotype that specializes them for a role in delayed repolarization. Mammalian Erg currents rectify during depolarization due to rapid, voltage-dependent inactivation, but rebound during repolarization due to a combination of rapid recovery from inactivation and slow deactivation. This is ex...
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