Background: Osteoarthritis is a slowly progressive disease of the diarthrodial joints. With articular cartilage degeneration, chondrocytes undergo mitosis and clustering. Degeneration changes its biomechanical, biochemical, structural properties. Numerous, non-invasive treatment options are available with emphasis on pain management, improvement in function potential to modify process progress ...

Abstract Background Pain in osteoarthritis (OA) has been attributed traditionally to local tissue injury causing ‘nociceptive pain’. However, recent studies suggest that neuropathic and central sensitization mechanisms may contribute the pain experience. relationship between these physical function not thoroughly addressed. This study aimed assess association of with knee OA. Results Participan...

Objective To examine the associations of knee injury, radiographic osteoarthritis severity, and quadriceps strength with pain exacerbation during walking. Design Within-person knee-matched case-control study. Methods Participants from Osteoarthritis Initiative who completed a 20-m walking test at 24-month visit were included. Pain was defined as an increase in intensity 1 or more on numeric rat...

Osteoarthritis (OA) of the knee is a common disorder that contributes to physical decline and activity limitation. Early OA diagnosis treatment can stop disease's progression. The assessment physician's visual examination impartial, subject different interpretations, highly dependent on their level experience. Therefore, system employs machine learning techniques automatically determine degree ...

Background: Symptomatic knee osteoarthritis (OA) is typically treated with hyaluronan-based intra-articular injections. Advanced OA patients are often unresponsive to hyaluronan. KiOmedine ® Carboxymethyl-Chitosan (CM-Chitosan), a novel fluid implant, was safe and effective for treating symptomatic OA. Objective: The objective of this study describe the efficacy single injection CM-Chitosan in ...

Knee joint instability is frequently reported by patients with knee osteoarthritis (KOA). Objective metrics to assess are lacking, making it difficult target therapies aiming improve stability. Therefore, the aim of this study was compare responses in neuromechanics perturbations during gait self-reported (KOA-I) versus reporting stable knees (KOA-S) and healthy control subjects. Forty (20 KOA-...

Amaç:Osteoartrit, çoğunlukla dizleri etkileyen en yaygın eklem hastalığıdır. Son yıllarda, düşük dereceli kronik inflamasyonla seyreden multifaktöriyel bir hastalığın osteoartrit patogenezinde rol oynadığı düşünülmektedir. Bu çalışmanın amacı diz osteoartriti olan hastalarda radyolojik evreleri ve hastanın günlük yaşam aktivite düzeyleri ile serum kıkırdak oligomerik matriks proteini (COMP) met...