Psoriasis appears in most cases to be a genetic disease in which stratified squamous epithelium (epidermis) of skin in involved versus normal-appearing uninvolved areas has the following prototypic features: (1) excessive cell proliferation and an accelerated cell cycle of the proliferating cells '; (2) incomplete epidermal specialization (keratinization) for tissue function; and (3) marked inc...

BACKGROUND Human papillomavirus-associated oropharyngeal carcinoma (HPV-OPC) is clinicopathologically distinct entity from the HPV-unassociated one (nHPV-OPC). This study aimed to determine the relationship between histological subtypes of OPC and HPV status for Japanese cases and to identify histological structures of HPV-OPC. METHODS 66 OPC cases were categorized into conventional squamous ...

Non-bullous congenital ichthyosiform erythroderma (NBCIE) is a hereditary disorder of keratinization caused by pathogenic variants in genes encoding enzymes important to lipid processing and terminal keratinocyte differentiation. Impaired function of these enzymes can cause pathologic epidermal scaling, significantly reduced skin barrier function. In this study, we have performed a focused, gen...

Pachyonychia congenital (PC), is a rare genetic disorder, autosomal dominant, disorder of keratinization. This condition characterized by cutaneous manifestation mainly hyperkeratosis skin and mucosae hypertrophy nails. In this condition, almost 50% the patients will have oral leukokeratosis. The case report here 15 years old girl, presented with dystrophic, thickened fingernails toenails subun...

Darier’s disease results from abnormal keratinization of skin and is characterized by numerous keratotic papules that preferentially involve seborrheic areas. Kaposi’s varicelliform eruption (KVE) occurs by viral infections such as herpes simplex virus (HSV) in some inflammatory skin disorders like Darier’s disease. Herein, we describe a 68-year-old man, a known case of Darier’s disease, who pr...

Bullous ichthyosiform erythroderma (BIE) is a rare disorder of keratinization (mutations in either keratin 1 or 10). It typically presents with fragile skin, which gives way to gradual evolutionof hyperkeratosis. Flaccid blisters, peeling, and superficial erosions at sites of minor trauma or friction are apparent within the first few hours of life. Yellow-brown, waxy, ridged or corrugated...