Cryptococcus neoformans is an encapsulated yeast that typically causes illness in immunocompromised hosts. Manifestations of the disease include pulmonary, Central Nervous System (CNS), and rare skeletal involvement. Optimal antifungal therapy for involvement has yet to be established. Here we present a potential regimen disseminated cryptococcal with pulmonary patient Chronic Lymphocytic Leuke...

Treatments for disease in the central nervous system (CNS) are limited because of difficulties agent penetration through blood-brain barrier, achieving optimal dosing, and mitigating off-target effects. The prospect precision medicine CNS treatment suggests an opportunity therapeutic nanotechnology, which offers tunability adaptability to address specific diseases as well targetability when com...

Prion diseases are characterized by deposition of PrP, a misfolded and aggregated isoform of the host-encoded cellular prion protein (PrP), within the central nervous system (CNS) and other organs. Here we review the current knowledge on five issues relevant to prion diseases: (1) how do prions enter the body, (2) how do prions reach the central nervous system, (3) how do prions damage the CNS,...

in this paper the simulation of pathological behavior in gait locomotion of central nervous system (cns) diseases and effects of rehabilitation techniques are investigated. these simulations noticeably deepen the knowledge of researches in neurorehabilitation realm about the neuroscientific basis of cns treatment after a neural disorder. however, only a limited number of these simulations have ...

background: central nervous system (cns) relapse in acute lymphoblastic leukemia was significantly decreased due to the use of new chemotherapyeutic agents, intrathecal chemotherapy and cranial irradiation. the purpose of this study was to compare the effectiveness of intrathecal (it) cns chemotherapy alone versus combination of it chemotherapy with cranial irradiation for prevention of cns rel...

Ganglioglioma is an infrequent tumor of the central nervous system (CNS); mostly supratentorial region. But, they can occur anywhere in the central nervous system such as brainstem, cerebellopontine angle (CPA), thalamus, optic nerve and spinal cord. Although it occurs rarely, ganglioglioma should be included in the differential diagnosis of a posterior fossa mass because early recognition is i...

Melioidosis is a disease of humans and animals which caused by motile Gram-negative bacilli, Burkholderia pseudomallei. Clinical presentation melioidosis can vary according to the site infection it mimic various other diseases. Central nervous system (CNS) rare but has high mortality rate. A index clinical suspicion, early diagnosis, prompt antibiotic treatment are important for better outcome....

post-traumatic stress disorder (ptsd) is an anxiety disorder that can typically occur after traumatic events in which the individual felt sever helplessness or horror. ptsd has a lifetime prevalence of 5–8% and women show higher prevalence than in compared with men. neuroinflammation is associated to anxiety and related disorders such as ptsd. it is an early, specialized immune reaction fallowi...