A terbium complex has been designed that may be used to sensitise formation of singlet oxygen (phi(em) 12%), allowing the creation of a ratiometric sensory system for pO(2) (versus the insensitive Eu analogue) and the definition of a reactive probe that can be used to cause local damage to cells loaded with the complex and exposed to laser excitation.

OBJECTIVES The pharmacodynamics of tuberculosis (TB) treatment should be further explored, to prevent emergence of resistance, treatment failure and relapse of infection. The diagnostic drug susceptibility tests guiding TB therapy investigate metabolically active Mycobacterium tuberculosis (Mtb) isolates under static conditions and as such are not informative with respect to the time-kill kinet...

Cord factor (trehalose 6,6'-dimycolate[TDM] ), a mixture of 6,6'-diesters of alpha, alpha-D-trehalose with natural mycolic acids, has been described as having immunoregulatory and antitumor activities in vivo, although the relevant mechanisms of action remain unelucidated. In this work, we measured the effects of TDM on both mouse macrophage association with (i.e., the combined result of surfac...

The yield of sweet potato vines is large, making it a good source food. However, difficult to harvest due creeping and intertwining. Therefore, according the domestic planting model, this paper designed double roll vine harvester which can complete operations picking, killing, conveying header harvesting at one time. machine adopts process front rear killing rod bar lifting. key components pick...

Pharmacodynamic modeling has been increasingly used as a decision support tool to guide dosing regimen selection, both in the drug development and clinical settings. Killing by antimicrobial agents has been traditionally classified categorically as concentration-dependent (which would favor less fractionating regimens) or time-dependent (for which more frequent dosing is preferred). While intui...

George Floyd’s killing brought us together for this special issue.A year later, we wrapped up the manuscripts issue and witnessed trial conviction of Derek Chauvin. killing...

IN connection with an experiment involving the killing rate of daphnids by mercuric chloride' it seemed desirable to test the resistance of the different ages and sexes of these animals to the poison. The animals were Daphnia magna, grown in the laboratory at Iowa City in the culture medium of Banta.2 All those used for the age experiment were parthenogenetic females of the same clone; those of...

Bacterial and viral contamination of touch surfaces allows for transmission of pathogens leading to increased risk of infection. Previous work has demonstrated the antimicrobial properties of copper for contact-killing of microbes for use in hospitals. Less research exists on copper as an antiviral surface and on the effects of nanomaterial copper surfaces in the contact-killing of viruses. Nan...

The survival ratios of colon bacilli subjected to several monochromatic ultraviolet radiations follow semilogarithmic straight lines. For each wave length approximate observations have been made of the energy involved in cell destruction. This energy varies somewhat with frequency in the ultraviolet region; it is furthermore nearly one hundred times as great as the amount of X-ray energy requir...

In this study we present a model of in vitro cell killing through type II Photodynamic Therapy (PDT) for simulation of the molecular interactions leading to cell death in time domain in the presence of oxygen transport within a spherical cell. By coupling the molecular kinetics to cell killing, we develop a modeling method of PDT cytotoxicity caused by singlet oxygen and obtain the cell surviva...