Although modern statistical computing will often be the method of choice for analyzing kinetic data, graphic methods provide an important supplement that ought not to be neglected. Residual plots, or plots of differences between observed and calculated values against variables not expected to be correlated with these differences, permit a rapid judgment of whether data have been correctly inter...

RNA sequences fold into their native conformations by means of an adaptive search of their folding energy landscapes. The energy landscape may contain one or more suboptimal attractor conformations, making it possible for an RNA sequence to become trapped in a suboptimal attractor during the folding process. How the probability that an RNA sequence will find a given attractor before it finds an...

We present a general algorithm for computing the effective diffusion coefficient of a general class of biomolecular transport processes. The method can be applied to spatially discrete and continuous processes and takes into account the effects of thermal diffusion and chemical kinetics. To provide an illustration of the algorithm, the problem of protein translocation is considered.

A criticism [Cornish-Bowden (1976) Biochem. J. 159, 167] of an algebraic method for deriving steady-state rate equations [Indge & Childs (1976) Biochem. J. 155, 567-570] is theoretically founded.

Michaelis and Menten's mechanism for enzymatic catalysis is remarkable both in its simplicity and its wide applicability. The extension for reversible processes, as done by Haldane, makes it even more relevant as most enzymes catalyze reactions that are reversible in nature and carry in vivo flux in both directions. Here, we decompose the reversible Michaelis-Menten equation into three terms, e...

Calcium carbonate is a versatile mineral with diverse industrial applications. Drying is a necessary processing step in preparation of calcium carbonate product. Deep knowledge of drying kinetics is required in order to design an appropriate dryer. The main aim of the present study was to investigate the drying kinetics of calcium carbonate, experimentally. Thirteen empirical correlations with ...

Cardiac sodium channels are integral membrane proteins whose structure is not known at atomic level yet and their molecular kinetics is still being studied through mathematical modeling. This study has focused on adapting an existing model of cardiac Na channel to analyze molecular kinetics of channels at 9-37°C. Irvine et al developed a Markov model for Na channel using Neuronal Network Model ...

Cardiac sodium channels are integral membrane proteins whose structure is not known at atomic level yet and their molecular kinetics is still being studied through mathematical modeling. This study has focused on adapting an existing model of cardiac Na channel to analyze molecular kinetics of channels at 9-37°C. Irvine et al developed a Markov model for Na channel using Neuronal Network Model ...

Background: Exposure to ionizing radiation is known to induce oxidative stress followed by damage to critical biomolecules like lipids, proteins and DNA through radiolysis of cellular water. Since radiation has been widely used as an important tool in therapy of cancer, the detailed investigation regarding the DNA damage and repair kinetics would help to predict the radiation sensitivity of cel...