background: presence of heavy metals in leachate due to the biological accumulation characteristics of these materials endangered the living creatures' health especially human. purpose of this study is to study and investigate the possibility of two metals' absorption i.e, lead and cadmium from leachate by natural zeolite clinopteliolit and increase of the ability to absorb the zeolite by modif...

The supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) represents a new thermodynamically stable formulation approach wherein it is designed to contain a reduced amount of surfactant and a water-soluble polymer (precipitation inhibitor or supersaturated promoter) to prevent precipitation of the drug by generating and maintaining a supersaturated state in-vivo. The supersatur...

Intestinal transcellular permeability (P(m)), measured across cell lines such as Caco-2 cells in vitro, is often used for assessing oral drug absorption potential in humans. However, the quantitative link between in vitro permeability and apparent in vivo absorption kinetics, based on drug appearance in plasma, is poorly understood. In the current study, a novel absorption-disposition kinetic m...

A technique is described for preparation in the guinea pig of an in situ, isolated, vascularized gall bladder that exhibits normal absorptive functions. Absorption of labeled bile pigments from the gall bladder was determined by the subsequent excretion of radioactivity in hepatic bile. Over a wide range of concentrations, unconjugated bilirubin-(14)C was well absorbed, whereas transfer of conj...

based on driving force for crystallization of one-component gas hydrate, in this report an expression for the supersaturation for crystallization of multicomponent gas hydrate is derived. expressions for the supersaturation are obtained in isothermal and isobaric regimes. the results obtained are applied to the crystallization of hydrates of mixtures of methane plus ethane and can apply to othe...

A technique is described for preparation in the guinea pig of an in situ, isolated, vascularized gall bladder that exhibits normal absorptive functions. Absorption of labeled bile pigments from the gall bladder was determined by the subsequent excretion of radioactivity in hepatic bile. Over a wide range of concentrations, unconjugated bilirubin-14C was well absorbed, whereas transfer of conjug...