In the previous paper expressions for the partial molar energy and entropy at infinite dilution have been derived based on the inhomogeneous forms of the energy equation and the correlation expansion for the entropy. These expressions are here applied to a series of solutes of varying size in dense hard-sphere and Lennard-Jones solvents, some of which serve as reference systems for comparison w...

In the January 15, 2012, issue of Clinical Cancer Research, Kirkwood and colleagues published a study comparing the MEK inhibitor selumetinib with temozolomide in unselected metastatic melanoma. Although selumetinib did not improve survival or response, most responders had BRAF-activating mutations, and selumetinib has since demonstrated efficacy in BRAF-mutant melanoma. This study laid the gro...