Numerous enzymes hyperphosphorylate Tau in vivo, leading to the formation of neurofibrillary tangles (NFTs) in the neurons of Alzheimer's disease (AD). Compared with age-matched normal controls, we demonstrated here that the protein levels of WW domain-containing oxidoreductase WOX1 (also known as WWOX or FOR), its Tyr33-phosphorylated form, and WOX2 were significantly down-regulated in the neu...

Methylglyoxal (MG), a highly reactive α-dicarbonyl metabolite of glucose degradation pathways, protein and fatty acid metabolism, plays an important role in the pathogenesis of diabetic complications. Hyperglycemia triggers enhanced production of MG and increased generation of advanced glycation endproducts (AGEs). In non-enzymatic reactions, MG reacts with arginine residues of proteins to form...

Recently miR-182 has been reported to be over-expressed in prostate cancer (PC) tissues, however detailed functional analysis of miR-182-5p has not been carried out. The purpose of this study was to: 1. analyze the function of miR-182-5p in prostate cancer, 2. assess its usefulness as a tumor marker, 3. identify miR-182-5p target genes in PC, 4. investigate the potential for miR-182-5p inhibito...

BACKGROUND The Meis1 protein represents an important cofactor for Hox and Pbx1 and is implicated in human and murine leukemias. Though much is known about the role of meis1 in leukemogenesis, its function in normal hematopoiesis remains largely unclear. Here we characterized the role of the proto-oncogene, meis1, during zebrafish primitive and definitive hematopoiesis. DESIGN AND METHODS Zebr...

Abstract Genomic instability is a key driving force for cancer development and age-related disease. While DNA damage responses are known to regulate genome integrity cell fates, there mounting evidence that genomic can trigger inflammatory and/or antitumor via pattern recognition receptors (PRRs) located in the cytosol. One such PRR, cyclic GMP-AMP synthase (cGAS), canonically detects foreign v...

South Sumatra has a lot of traditional houses across its region. Each house own characteristics. One notable design is built on stilts. In Ogan Ilir, especially Tanjung Batu, it famous for the production knock-down houses. Knock-down in Batu are stilt with an architectural that almost resembles Limas house, only these specially designed to make easy disassemble and reassemble them elsewhere. Th...

Abstract Background Prostate cancers frequently metastasize to bone, where the best microenvironment for distant colonization is provided. Since osteotropic metastasis of prostate cancer a critical determinant patients’ survival, searches preventive measures are ongoing in field. Therefore, it important dissect mechanisms each step bone metastasis, including epithelial-mesenchymal transition (E...

The transcriptional corepressor SIN3 is an essential gene in metazoans. In cell culture experiments, loss of SIN3 leads to defects in cell proliferation. Whether and how SIN3 may regulate the cell cycle during development has not been explored. To gain insight into this relationship, we have generated conditional knock down of Drosophila SIN3 and analyzed effects on growth and development in th...

OBJECTIVE To examine the association between fragile X mental retardation protein (FMRP) expression and astrocytoma characteristics. METHODS Pathologic grade and expressions of glial fibrillary acidic protein (GFAP), Ki67 (proliferation marker), and FMRP were determined in astrocytoma specimens from 74 patients. Kaplan-Meier survival analysis was undertaken. Pathologic grade and protein level...