Summary Cardiac amyloidosis is caused by deposition of abnormally folded proteins (amyloid). The most common forms which present with cardiac involvement are light-chain (AL) and transthyretin (ATTR). Even novel treatments emerging, the prognosis these patients remains poor once amyloid deposits in heart. Therefore, knowledge on clinical imaging features crucial to make an early diagnosis impro...

The discovery that Philadelphia-negative classical myeloproliferative neoplasms (MPNs) present with several molecular abnormalities, including the mostly represented JAK2V617F mutation, opened new horizons in the diagnosis, prognosis, and monitoring of these disorders. However, the great strides in the knowledge on molecular genetics need parallel progresses on the best approach to methods for ...

Hepatocellular carcinoma (HCC) is a common tumor. Although the diagnosis and treatment of HCC have made great progress, overall prognosis remains poor. As core component artificial intelligence, machine learning (ML) has developed rapidly in past decade. In particular, ML become widely used medical field, it helped cancer. Different algorithms different roles diagnosis, treatment, prognosis. Th...

The paper presents the results of the development of the knowledge base for the HEARTFAID platform. The means and methods used to collect, systematize and formalize medical knowledge, as well as to test the developed knowledge representation are described. The descriptive part of the knowledge base is realized as an ontology which conceptualizes the heart failure medical domain. The procedural ...

OBJECTIVE Testis cancer is the most common cancer in young men, and its incidence continues to rise. Even if prognosis is considered as good, a group with bad prognosis still remains. Diagnostic delay (DD), defined as the time elapsing from the onset of tumour symptoms to the day of diagnosis, is a way to evaluate the rapidity of diagnosis. We assessed the relationship between DD, disease stage...

Background: Hemophilic pseudotumor is a rare lesion that is progressive and expansile by nature. It is a hematoma or a blood cyst surrounded by a fibrous capsule. Case report: A 7-years-old boy was referred with a painless swelling in the mandible, bleeding and problem in mastication. Due to a late diagnosis, the patient went untreated for almost a year. After detailed examination and taking m...

OBJECTIVE In most studies, treatment decisions of brainstem glioma are based solely on MRI features and do not incorporate a histopathological diagnosis. In the current study, we sought to compare MRI characteristics with histopathological findings of bainstem glioma. METHODS From April 2003 through April 2012, 150 patients were diagnosed with brainstem gliomas by MRI and microsurgically trea...

Down syndrome (Trisomy 21) is one of the commonest chromosomal disorders which occur in one in 650-1000 live births. Mental retardation, dysmorphic facial features and other distinctive phenotypic traits characterize the Down syndrome [1]. A precise diagnosis makes available all the accumulated knowledge and experience of that condition and generally provides a better estimate of the risk of re...