It has been documented that telomere-associated cellular senescence may contribute to certain age-related disorders, and telomere length (TL) may be an informative biomarker of healthy aging. Hormone-brain-aging behavior-modulated telomere dynamics and changes in telomerase activity are consistent elements of cellular alterations associated with changes in proliferative state, and these process...

Carnosine is a naturally occurring pleotropic dipeptide which influences multiple deleterious mechanisms that are activated during stroke. Numerous published studies have reported that carnosine has robust efficacy in ischemic stroke models. To further evaluate these data, we have conducted a systematic review and meta-analysis of published studies. We included publications describing in vivo m...

Carnosine has been shown to react with low-molecular-weight aldehydes and ketones and has been proposed as a naturally occurring anti-glycating agent. It is suggested here that carnosine can also react with ("carnosinylate") proteins bearing carbonyl groups, and evidence supporting this idea is presented. Accumulation of protein carbonyl groups is associated with cellular ageing resulting from ...

BACKGROUND To examine the effect of carnosine on liver function and histological findings in experimental septic shock model, 24 Sprague-Dawley rats were used. MATERIAL/METHODS Rats were divided into control, septic shock, and carnosine-treated septic shock groups. Femoral vein and artery catheterization were performed on all rats. Rats in the control group underwent laparotomy and catheteriz...

Introduction: Carnosine (ß-alanyl-L-histidine) is a cytoplasmic dipeptide found in high concentrations in skeletal muscle, particularly in type II muscle fibers. Chronic (~4 weeks) ß-alanine (BA) supplementation (~5g BA/day) has been shown to increase muscle carnosine contents by >50%, which can contribute ~15% towards total intracellular muscle buffering capacity. However, the optimal BA dosin...

Previous studies have demonstrated that central injection of L-carnosine (beta-alynyl-L-histidine), dipeptide synthesized in mammalian muscles, affects renal sympathetic nerve activity (RSNA) and blood pressure (BP) in anesthetized rats. In the present study, using urethane-anesthetized rats, we examined the dose-dependent effects of intravenous (IV) injection of various doses of anserine, dipe...

Carnosine, homocarnosine, and anserine are present in high concentrations in the muscle and brain of many animals and humans. However, their exact function is not clear. The antioxidant activity of these compounds has been examined by testing their peroxyl radical-trapping ability at physiological concentrations. Carnosine, homocarnosine, anserine, and other histidine derivatives all showed ant...

Sir, Carnosine, an endogenously synthesized dipeptide found in muscular and other tissues, was reported to possess antioxidant properties. Favorable actions of carnosine were explained by its effects against reactive oxygen species (ROS), against peroxynitrite damage and different types of viral injury [1-6]. Moreover, one of the mechanisms of detoxification from aldehydes, accumulating in infl...