George Voronoi (1908, 1909) introduced two important reduction methods for positive quadratic forms: the reduction with perfect forms, and the reduction with Ltype domains, often called domains of Delaunay type. The first method is important in studies of dense lattice packings of spheres. The second method provides the key tools for finding the least dense lattice coverings with equal spheres ...

There are great demands on the stability, expression yield and resistance to aggregation of antibody fragments. To untangle intrinsic domain effects from domain interactions, we present first a systematic evaluation of the isolated human immunoglobulin variable heavy (V(H)) and light (V(L)) germline family consensus domains and then a systematic series of V(H)-V(L) combinations in the scFv form...

The purposes of this paper are (i) to give a new, eecient representation of Smyth powerdomains as 0-inhabited information systems, following the style of Scott; (ii) to introduce, as a consequence of this representation, a generalized resolution method for an arbitrary Smyth powerdomain and show the soundness and completeness of this method. The connection of (i) with (ii) comes from the observ...

The major challenge in the generation of bispecific IgG antibodies is enforcement of the correct heavy and light chain association. The correct association of generic light chains can be enabled using immunoglobulin domain crossover, known as CrossMAb technology, which can be combined with approaches enabling correct heavy chain association such as knobs-into-holes (KiH) technology or electrost...

Foamy viruses (FV) are unusual among retroviruses since they require both Gag and Env structural proteins for particle egress. Recently significant progress has been made towards the mechanistic understanding of the viral release process, in particular that of retroviruses, and the viral domains and cellular pathways involved. However little is currently known about domains of FV structural pro...

A parametric analysis is an analysis whose input and output are parametrized with a number of parameters which can be instantiated to abstract properties after analysis is completed. This paper proposes to use Cousot and Cousot’s Cardinal power domain to capture dependencies of analysis output on its input and obtain a parametric analysis by parametrizing a base analysis. We illustrate the meth...

Allergic responses result from the activation of mast cells by the human high-affinity IgE receptor. IgE-mediated allergic reactions may develop to a variety of environmental compounds, but the initiation of a response requires the binding of IgE to its high-affinity receptor. We have solved the X-ray crystal structure of the antibody-binding domains of the human IgE receptor at 2.4 A resolutio...

No effective therapeutic is currently in place for improved case management of severe measles or the rapid control of outbreaks. Through high-throughput screening, we recently identified a novel small-molecule class that potently blocks activity of the measles virus (MeV) RNA-dependent RNA polymerase (RdRp) complex in transient replicon assays. However, the nature of the block in RdRp activity ...

In addition to PTAP L domains, primate lentiviruses carry Alix-binding motifs that include the recently described type 3 SREKPYKEVTEDLLHLNSLF sequence. We examined the requirements for the type 3 sequence motif in simian immunodeficiency virus SIV(smE543) and identified the (499)LNSLF(503) sequence as a key functional determinant. Mutation of distal leucines (499)L and (502)L (LL mutant) caused...