In the light of recent developments in optimal real L1-norm principal-component analysis (PCA), we provide the first algorithm in the literature to carry out L1-PCA of complexvalued data. Then, we use this algorithm to develop a novel subspace-based direction-of-arrival (DoA) estimation method that is resistant to faulty measurements or jamming. As demonstrated by numerical experiments, the pro...

Background KD033 is a clinical-stage bispecific fusion molecule consisting of high-affinity anti-human-PD-L1 antibody and human IL-15. Previous studies with in mice expressing functional PD-1 PD-L1 showed that was efficacious reducing the growth both positive negative tumors. 1 In microenvironment tumors, would still be expressed by some immune cells such as macrophages. The goal current study ...

Murine 3T3-L1 adipocytes are widely used as a cellular model of obesity. However, whereas transfection of 3T3-L1 preadipocytes is straightforward, ectopic gene expression in mature 3T3-L1 adipocytes has proved challenging. Here, we used the pSLIK vector system to generate stable doxycycline-inducible expression of the liver-enriched inhibitor protein isoform of CCAAT/enhancer binding protein β ...

Hyperspectral unmixing is a crucial preprocessing step for material classification and recognition. In the last decade, nonnegative matrix factorization (NMF) and its extensions have been intensively studied to unmix hyperspectral imagery and recover the material end-members. As an important constraint for NMF, sparsity has been modeled making use of the L1 regularizer. Unfortunately, the L1 re...

We have previously identified cis-acting RNA sequences in the human papillomavirus type 16 (HPV-16) L1 coding region which inhibit expression of L1 from eukaryotic expression plasmids. Here we have determined the function of one of these RNA elements, and we provide evidence that this RNA element is a splicing silencer which suppresses the use of the 3' splice site located immediately upstream ...

Although circulating tumor cells (CTCs) have potential as diagnostic biomarkers for cancer, determining their prognostic role in cancer patients undergoing treatment is a challenge. We evaluated the prognostic value of programmed death-ligand 1 (PD-L1) expression in CTCs in colorectal and prostate cancer patients undergoing treatment. Peripheral blood samples were collected from 62 metastatic c...

Feature selection is a technique to screen out less important features. Many existing supervised feature selection algorithms use redundancy and relevancy as the main criteria to select features. However, feature interaction, potentially a key characteristic in real-world problems, has not received much attention. As an attempt to take feature interaction into account, we propose l1-LSMI, an l1...

Pancreatic ductal adenocarcinoma (PDAC) is considered a non-immunogenic tumor, and immune checkpoint inhibitor monotherapy lacks efficacy in this disease. Radiotherapy (RT) can stimulate the immune system. Here, we show that treatment of KPC and Pan02 murine PDAC cells with RT and gemcitabine upregulated PD-L1 expression in a JAK/Stat1-dependent manner. In vitro, PD-L1 inhibition did not alter ...

This article presents the results of a perception study of foreign phonemes, in particular, Polish phonemes categorized by Croatian native listeners. Our experiment shows that listeners can identify phonemes of an unknown/new language (L2) without having had prior training in this new language if the phonemes utilize the same phonological distinctive features as employed in the native language ...