OBJECTIVE To investigate the association of gestational age and mode of birth with early child development. METHODS Population-based record linkage cohort study was conducted among 153 730 live-born infants of ≥32 weeks' gestation with developmental assessments at school age, in New South Wales, Australia, 2002 to 2007. Children were assessed in 5 domains: physical health and well-being, lang...

BACKGROUND In childbirth, most deliveries are low-risk, defined as spontaneous labor at full term without special high-risk facts or complications, especially in high-resource countries where maternal and perinatal mortality rates are very low. Indeed, the majority of mothers and infants have no serious conditions during labor. However, the quality of care provided is not assured, and performan...

AIM To determine whether maternal obesity is associated with dysfunctional labor patterns. METHODS In a case-control design we compared the graphic labor patterns of a group of 105 very obese subjects [body mass index (BMI) >35 kg/m(2)] with those of 113 lean controls (BMI<26 kg/m(2)). All entered spontaneous labor at term. Cases with birth weights >4 kg, diabetes mellitus, hypertension and p...

Preterm birth is defined as birth before the completion of 37 weeks of gestation. The frequency of preterm birth in the United States increased from 10.7% in 1992 to 12.3% in 2003. 1 Preterm births can be categorized as those undertaken because of a specific indication or as spontaneous preterm births. Indicated preterm births occur when a health care provider delivers a baby because of medical...

The oxytocin/oxytocin receptor (OXT/OXTR) system plays an important role in the regulation of parturition. The amnion is a major source of prostaglandins and inflammatory cytokine synthesis, which increase both before and during labor. Amnion is a noncontractile tissue; therefore, the role played by OXT/OXTR in this tissue will be fundamentally different from the role played in myometrial contr...

Prostaglandins (PGs) have proven important during parturition, but inhibition of PG production treating preterm labor (PTL) results in significant maternal and fetal side effects. We hypothesize that specific inhibition of either cyclooxygenase (COX)-1 or -2 may result in separation of therapeutic and toxic effects. We demonstrate that COX-2, but not COX-1, is induced during inflammation-mediat...

OBJECTIVES To compare uterine rupture, maternal and perinatal morbidity rates in women with one single previous cesarean after spontaneous onset of labor or low-dose prostaglandin-induced cervical ripening for unfavourable cervix. STUDY DESIGN This was a retrospective cohort study of 4,137 women with one single previous cesarean over a 22-year period. Inpatient prostaglandin administration co...

BACKGROUND The placenta is the major source of oxidative stress in normal human pregnancy. The placental tissue is typically functional in postterm pregnancies. We hypothesized that such pregnancies experience deteriorating oxidative balance and increasing oxidative stress. In this case-control study, our aim was to investigate the oxidative status in postterm pregnancies comparing with term by...

OBJECTIVE The complement system plays a central role in the first line of defense against invading pathogens, and its activation involves the release of potent pro-inflammatory mediators such as anaphylatoxins C3a, C4a and C5a. The aim of this study was to determine whether differences existed in maternal plasma anaphylatoxin concentrations between patients with term and preterm parturition. ...

effect of aromatherapy with essential damask rose oil on anxiety of the active phase of labor nulliparous women     kheirkhah m [1] ,setayesh valipour n* [2] ,neisani samani l [3] ,haghani h [4]     received: 4 may, 2013 accepted: 16 jul, 2013    abstract  background & aims : anxiety in women during labor is the most common emotional reactions and undesirable effects on the fetus and the mother...