introduction: laser surgery as an alternative for conventional surgical procedure has gained special attention. using carbon dioxide (co2) laser has some benefits like less post-operative pain, swelling and infection, decrease in risk of metastasis and edema, and less bleeding providing dry sites for surgery. case report: a 12 years old boy with lingual frenum with indication for excision was r...

statement of problem: the achievement of a good and durable dentin/composite resin bond is an important task in restorative dentistry. the application of acid conditioners and dentin bonding agents is an accepted method to enhance this bond strength. pretreating of dentin surface by laser irradiation seems to be a supplemental way to obtain better results, since lased dentin is more roughened a...

introduction: dentine hypersensitivity (dh) is characterized by a short sharp pain arising from the exposed dentine, in response to a thermal, evaporative, tactile, osmotic or chemical stimulus. the aim of this study was to evaluate the efficacy of nd:yag laser therapy and desensitizing gel (sensikin®, laboratorios kin s.a., barcelona, spain) in treatment of dentine hypersensitivity. methods: a...

Optogenetic neuronal network manipulation promises to unravel a long-standing mystery in neuroscience: how does microcircuit activity relate causally to behavioral and pathological states? The challenge to evoke spikes with high spatial and temporal complexity necessitates further joint development of light-delivery approaches and custom opsins. Two-photon (2P) light-targeting strategies demons...

Cells can be transfected by transient laser-induced perforation of the cell membrane which allows foreign genetic material to enter the cell interior. This method (“optoporation”) has emerged as a powerful noninvasive and highly efficient cell-transfection technique. A detailed comparison of efficiencies and results, however, is often hindered by different experimental setups and lasers used in...

Resistance to regular treatment strategies is a big challenge in the treatment of castration-resistant prostate cancer. Combination of photothermal and photodynamic therapy (PTT/PDT) with chemotherapy offers unique advantages over monotherapy alone. However, free drugs, such as photosensitizers and chemotherapeutic agents, lack tumor-targeted accumulation and can be easily eliminated from the b...

A new approach for Quartz Enhanced Photoacoustic Spectroscopy is presented, based on an acoustic excitation from the outside of prongs a quartz tuning fork, to increase sensitivity sensor. For this purpose, we introduce monolithic double-resonator (double-mR) in T-shape configuration, using 3D printing. It was modelized and experimentally characterized 1392 nm distributed feedback laser diode, ...

Mitochondria are organelles that are readily susceptible to temperature elevation. We selectively delivered a coumarin-based fluorescent iron oxide nanoparticle, Mito-CIO, to the mitochondria. Upon 740 nm laser irradiation, the intracellular temperature of HeLa cells was elevated by 2.1 °C within 5 min when using Mito-CIO, and the treatment resulted in better hyperthermia and a more elevated cy...

After nearly three decades of innovation in excimer laser, today we are presented with a state of the art generation targeting minimally invasive refractive surgery with high speed laser, faster trackers, pupil monitoring systems and better customization profiles. These systems are capable of delivering better treatments with less induced postoperative high order aberrations. The results report...

For the last two decades adaptive optics has been used as a technique for correcting imaging applications and directed energy/laser targeting and laser communications systems affected by atmospheric turbulence. Typically these systems are bulky and limited to <10 kHz due to large computing overhead and limited photon efficiencies. Moreover most use zonal wavefront sensors which cannot easily ha...