Aggregation is generally a time consuming process that is only marginally suited for interactive result exploration. This work presents a framework of techniques to support an extended aggregation that works online and is controllable by user feedback. Supportive visualisation methods are presented as well as an overview of applicable interaction techniques and a generic architecture combining ...

When tobacco is smoked, chewed or snuffed, nicotine is absorbed by the lungs or mucous membrane and quickly moved into the bloodstream, where it is circulated throughout the brain. In fact nicotine is highly dangerous to be consumed in any form. The present study was conducted to know the adverse effects of nicotine on the platelet aggregation in cerebral microvessels of mice. Male mice of aver...

In clinical trials with multiple visits, dropouts often occur and the population of patients who dropped out may be different from the population of patients who completed the study. To assess treatment effects over the population of all randomized patients, which is called the intention-to-treat analysis and is required by regulatory agencies, last observation analysis (LOAN) focuses on the la...

In many longitudinal studies, the covariates and response are often intermittently observed at irregular, mismatched and subject-specific times. Last observation carried forward (LOCF) is one of the most commonly used methods to deal with such data when covariates and response are observed asynchronously. However, this can lead to considerable bias. In this paper, we propose a weighted LOCF est...

In the author line, the names of the authors appear incorrectly, with the surname first. The correct author line appears above.

Bandwidth in the Internet is constantly increasing. The last mile problem of the Internet has almost been solved. Multimedia has emerged as the favorite mode of information dispersal on the net. Multicast is increasingly being seen as the vehicle of choice for multimedia streams. What has been the one true stumbling roadblock in widespread deployment is the lack of DNS like structure for multic...

This paper focuses on network planning strategies for the global communications carrier. It discusses strategic planning for the provision of new data and Internet services, and assesses alternative network designs and technologies to provide optimized solutions and service delivery. The discussion covers the regional, metropolitan and local, or last mile, networks and related access technologi...

In the majority of countries, surnames represent a ubiquitous cultural attribute inherited from an individual's ancestors and predominantly only altered through marriage. This paper utilises an innovative method, taken from economics, to offer unprecedented insights into the "surname space" of the Czech Republic. We construct this space as a network based on the pairwise probabilities of co-occ...

There has been considerable controversy about whether this last entailment always holds. Ordinary subjects may judge that (4) and (5) are appropriate in cases in which none of (1)-(3) are—cases in which Jack’s breaking the base is a foreseen but undesired consequence of Jack’s intentionally doing something else. It is currently debated what the best explanation of such ordinary reactions might ...

Immune cells sense and react to a multitude of factors including both host and microbe-derived signals. Understanding how cells translate these cues into particular cellular behaviors is a complex yet critical area of study. We have previously shown that both neutrophils and macrophages are important for controlling the fish pathogen Streptococcus iniae. Here, we report both host and bacterial ...