The mammalian -globin loci each contain a family of developmentally expressed genes, and a far upstream regulatory element, the locus control region (LCR). In adult murine erythroid cells, the LCR and the transcribed -globin genes exist within domains of histone acetylation and RNA polymerase II (pol II) is associated with them. In contrast, the silent embryonic genes lie between these domains ...

BACKGROUND AND OBJECTIVES We sought to determine the relationship between mean platelet volume (MPV), platelet distribution width (PDW), and platelet larger cell ratio (P-LCR) with slow coronary flow (SCF). SUBJECTS AND METHODS Eighty participants who underwent coronary angiography were divided into two groups, 50 participants with SCF as case group, and 30 with normal coronary flow (NCF) as ...

BACKGROUND Although high aerobic capacity is associated with effective cardiac function, the effect of aerobic capacity on atrial function, especially in terms of cellular mechanisms, is not known. We aimed to investigate whether rats with low inborn maximal oxygen uptake (VO2 max) had impaired atrial myocyte contractile function when compared to rats with high inborn VO2 max. METHODS AND RES...

Inactivity-related diseases are becoming a huge burden on Western society. While there is a major environmental contribution to metabolic health, the intrinsic properties that predispose or protect against particular health traits are harder to define. We used rat models of inborn high running capacity (HCR) and low running capacity (LCR) to determine inherent differences in mitochondrial volum...

HE HUMAN p-GLOBIN locus contains five funcT tional genes arranged 5' E-Gy-Ay-6-P 3' in the order of their expression during development.' Six to 18 kb upstream of the eglobin gene are a series of four DNase I hypersensitive sites that are erythroid specific and developmentally stable, ie, present regardless of which specific globin genes are active.'z3 Reverse genetics experiments have shown th...

High-capacity running (HCR) rats are protected against the early (i.e., ∼ 11 wk postsurgery) development of ovariectomy (OVX)-induced insulin resistance (IR) compared with low-capacity running (LCR) rats. The purpose of this study was to utilize the hyperinsulinemic euglycemic clamp to determine whether 1) HCR rats remain protected from OVX-induced IR when the time following OVX is extended to ...

The mammalian b-globin locus is a multigenic, developmentally regulated, tissuespecific locus from which gene expression is regulated by a distal regulatory region, the locus control region (LCR). The functional mechanism by which the b-globin LCR stimulates transcription of the linked b-like globin genes remains unknown. The LCR is composed of a series of 5 DNaseI hypersensitive sites (5*HSs) ...

Ovariectomized rodents model human menopause in that they rapidly gain weight, reduce spontaneous physical activity (SPA), and develop metabolic dysfunction, including insulin resistance. How contrasting aerobic fitness levels impacts ovariectomy (OVX)-associated metabolic dysfunction is not known. Female rats selectively bred for high and low intrinsic aerobic fitness [high-capacity runners (H...

The C-terminal domain (CTD, aa 686-741) of nuclear factor-erythroid 2 p45-related factor 1 (Nrf1) shares 53% amino acid sequence identity with the equivalent Neh3 domain of Nrf2, a homologous transcription factor. The Neh3 positively regulates Nrf2, but whether the Neh3-like (Neh3L) CTD of Nrf1 has a similar role in regulating Nrf1-target gene expression is unknown. Herein, we report that CTD n...

In this article we introduce a new contention resolution algorithm called Look-ahead Window Contention Resolution (LCR). This unique contention resolution approach can be used in conjunction with a scheduling technique to reduce the packet loss in an optical burst switched network. We analyze the performance of LCR by means of simulations and compare it with other major existing contention reso...