نتایج جستجو برای: ldl cholesterol
تعداد نتایج: 98603 فیلتر نتایج به سال:
Because the association of hypertriglyceridemia and premature atherosclerosis is not due to the direct effects of the triglyceride molecule itself, we studied the effects of increased plasma triglyceride-rich lipoproteins on the composition and structure of low density lipoprotein (LDL) and high density lipoprotein (HDL). We found profound changes in the core and surface domains of both lipopro...
High serum cholesterol is a major risk factor for coronary heart disease (CHD), and most cholesterol in serum circulates with low density lipoproteins (LDLs). These lipoproteins are macromolecular complexes containing a core of nonpolar lipids — mainly cholesterol ester—and a surface coat of unesterified cholesterol, phospholipids, and apolipoprotein (apo) B-100. Many investigators believe that...
BACKGROUND Low-density lipoproteins (LDL) have been identified as the major atherogenic lipoproteins and have long been identified by the National Cholesterol Education Project (NCEP) as the primary target of cholesterollowering therapy. LDL particles consist of a surface coat composed of phospholipids, free cholesterol, and apolipoproteins, surrounding an inner lipid core composed of cholester...
with our data and study design. The comment of Kalman and Colker regarding nutrient analysis is also incorrect. Besides the analysis of macronutrients and isoflavones, we also calculated total cholesterol and saturated, monounsaturated, and polyunsaturated fat, as stated in the paper. Soy intake was also known because the only form of soy consumed was the one provided in the test protein (1). R...
To explore the role of LDL in caveolin-Ras regulation in human endothelial cells (ECs), we incubated confluent human umbilical vein endothelial cells (HUVECs) with LDL. This resulted in a high steady-state caveolin-1 (Cav-1) expression at both the mRNA and protein levels. LDL exposure appeared not to regulate the abundance of Cav-1. Immunofluorescence staining showed that Cav-1 protein migrated...
These studies examine the regulation of plasma low density lipoprotein (LDL)-cholesterol levels by varying quantities of dietary saturated and polyunsaturated triacylglycerols. At a constant load of 0.12% cholesterol and 20% triacylglycerol, substitution of polyunsaturated for saturated triacylglycerols caused LDL receptor activity to increase from 25% to 80% of control and reduced the LDL-chol...
A therosclerosis is related to inflammatory conditions, which are initiated by invasion of low density lipoprotein (LDL) cholesterol (“the bad cholesterol”) into the artery wall. The early atherosclerotic lesion is characterized by the accumulation of cells loaded with cholesterol, which gain the appearance of foam cells. Elevated plasma levels of LDLcholesterol are major risk factors for cardi...
AIMS/INTRODUCTION Recently, patient-tailored statin therapy was proven effective for achieving target low-density lipoprotein (LDL) cholesterol levels. It is unclear, however, whether this therapeutic modality would be effective for atherogenic lipid profiles and inflammation in patients with type 2 diabetes. MATERIALS AND METHODS The present study was an 8-week, multicenter, single-step titr...
BACKGROUND Elevated nonfasting remnant cholesterol and low-density lipoprotein (LDL) cholesterol are causally associated with ischemic heart disease (IHD), but whether elevated nonfasting remnant cholesterol and LDL cholesterol both cause low-grade inflammation is currently unknown. METHODS AND RESULTS We studied 60 608 individuals from the Copenhagen General Population Study, the Copenhagen ...
The Lpb5 apolipoprotein B (apoB) allele occurs in pigs with spontaneous hypercholesterolemia. Low-density lipoprotein (LDL) from these pigs binds to the LDL receptor with a lower affinity and is cleared from the circulation more slowly than control pig LDL. However, the severity of hypercholesterolemia in pigs with the mutant apoB allele is highly variable. This study aimed to determine the met...
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