Uterine contractions are tightly regulated by the electrical activity of myometrial smooth muscle cells (MSMCs). These cells require a depolarizing current to initiate Ca(2+) influx and induce contraction. Cationic leak channels, which permit a steady flow of cations into a cell, are known to cause membrane depolarization in many tissue types. Previously, a Gd(3+)-sensitive, Na(+)-dependent lea...

IMPORTANCE Anastomotic leak is a potentially devastating complication of bowel surgery, yet a leak can refer to a range of clinical problems, with disparate treatment and outcomes. OBJECTIVES To qualitatively categorize the spectrum of anastomotic leaks that occur after low anterior resection for rectal cancer and to describe their effect on outcomes. DESIGN AND SETTING Retrospective review...

BACKGROUND AND PURPOSE Spinal CSF leak syndrome is a unique disorder caused by spinal CSF leak. In this study, we attempted to determine whether MR myelography (MRM) can detect the leakage site in the spine. MATERIALS AND METHODS We performed both MRM and radioisotope cisternography (RIC) in 15 patients with spinal CSF leak syndrome. Patients were included in this study if they had at least 2...

introduction: congenital anomalies of the cochlea and labyrinth can be associated with meningitis and varying degrees of hearing loss or deafness. despite antibiotics, meningitis remains a life threatening complication.   case report: we report a case of recurrent meningitis following episodes of otitis media in a cochlear implantee child with bilateral vestibulocochlear malformation, due to fi...

Highlights • real-time deflation experiments and analysis of the structural behavior thin membrane inflatable semi-empirical formulation a single leak, passive porous leakage active area coefficient load curves geometric changes structure's surface with photogrammetry collapse modeling space structure an implicit explicit fea We propose methodology for multi-objective characterization light, la...

5 patients who presented with CSF leaks between the years 2002-2009 were evaluated according to the etiology of the leak. An active CSF leak was confirmed in all patients and the site identified. A repair was planned using either vascularized septal mucosal flaps or free grafts of nasal mucosa. Preparation of the graft recipient site is important. A tissue glue either Tisseal or in the later ca...

We present a novel leak detection algorithm. To prove the absence of a memory leak, the algorithm assumes its presence and runs a backward heap analysis to disprove this assumption. We have implemented this approach in a memory leak analysis tool and used it to analyze several routines that manipulate linked lists and trees. Because of the reverse nature of the algorithm, the analysis can local...

The popularity of Android applications have grown dramatically in the last few years. Android applications run on mobile devices that have limited memory resources. Although Android has its own memory manager with garbage collection support, many applications currently suffer from memory leak vulnerabilities. These applications may crash due to out of memory error while running, and this will l...

A persistent pulmonary air leak, whether as a result of pulmonary surgery or as a result of a traumatic or spontaneous pneumothorax, is a difficult and frustrating problem to manage. Several therapies have been employed, including thoracotomy and repair of the air leak, prolonged tube thoracostomy suction, and chemical pleurodesis. We report two cases in which patients with a prolonged air leak...

A chyle leak can occur as a complication after neck or chest surgery. Such a leak prolongs the hospital stay and is sometimes life-threatening. The treatment options are conservative management, interventional radiologic embolization, and surgery. Thoracoscopic ligation of the thoracic duct has emerged as a promising and definitive treatment. The case of a 65-year-old Japanese male patient with...