This study investigated the effects of Carnosine on protein aggregation in cataract lenses of the eye using an in vitro model. Carnosine is a dipeptide of histidine and betaalanine and has many powerful properties such as retarding cancer growth and preventing glycation. To simulate the protein aggregation in a cataract lens, Methylgloxal, a product known for causing advanced glycation endprodu...

The structure, distribution, and nature of scattering elements associated with cold cataract formation in the young rat lens were studied in situ using light and electron microscopy and ImmunoGold electron microscopy. A large accumulation of spherical droplets, ranging from approximately 1.5 microns to 10 microns in diameter, were found in the lens nucleus in cold cataracts induced at 22 degree...

Cataracts, named for any opacity in the ocular lens, remain the leading cause of vision loss in the world. Non-surgical methods for cataract prevention are still elusive. We have genetically tested whether enhanced lens gap junction communication, provided by increased α3 connexin (Cx46) proteins expressed from α8(Kiα3) knock-in alleles in Gja8tm1(Gja3)Tww mice, could prevent nuclear cataracts ...

This study evaluated the role of anterior lens capsule vascularity in assessing gestation in small for gestational age (SGA) neonates in a prospective manner. Neonates with birth weight less than 2000 g were recruited. Those with gross congenital malformations, including corneal opacity or cataract and evidence of TORCH infection were excluded from the study. A total of 139 subjects were enroll...

Using Gayle Rubin’s (1984) classic distinction between “good sex” and “bad as a springboard, this article explores ideas of sexual normalcy otherness in Swedish context through the lens multi-method case study kink platform darkside.se (established 2003). The focuses on how norms beyond Darkside have shifted time, particular takes shape an ambivalent borderland new forms public visibility linge...

PURPOSE To examine the association of blood antioxidants with cataract. METHODS Cross-sectional study of people aged >or=50 years identified from a household enumeration of 11 randomly sampled villages in North India. Participants were interviewed for putative risk factors (tobacco, alcohol, biomass fuel use, sunlight exposure, and socioeconomic status) and underwent lens photography and bloo...

PURPOSE To investigate the process of repair in the epithelial cells and the reconstruction in lens fibers of a mouse lens that has developed opacity because of a large-scale perforating injury. METHODS Lenses of 4-week-old mice were perforated with a needle through the cornea to induce the development of traumatic cataracts. Over the period from the first day to the fifth month after injury,...

With the use of a freeze-sectioning technique, the existence of a centripetal protein gradient in the rabbit lens is demonstrated. The steepness of this gradient (the difference in the protein concentration between periphery and the center) varies with age: it increases from a value of 40% in 6- to 8-month-old lenses to 60% by the age of 4 to 5 years and then begins to decline at an average rat...

This study examined the contribution of the crystalline lens to the spatial contrast sensitivity loss experienced by many healthy older adults. Spatial contrast sensitivity was measured in three groups of adults: older adults who had undergone cataract extraction and intraocular lens (IOL) insertion; older adults who were in good ocular health (agematched to the first group); and young adults a...

Mutations in Peroxidasin (PXDN) cause severe inherited eye disorders in humans, such as congenital cataract, corneal opacity and developmental glaucoma. The role of peroxidasin during eye development is poorly understood. Here, we describe the first Pxdn mouse mutant which was induced by ENU (N-ethyl-N-nitrosourea) and led to a recessive phenotype. Sequence analysis of cDNA revealed a T3816A mu...