and hypertension. Annual report of the American Association of Poison Control Centers' National Poison Data System of 2008 revealed that out of 9,006 unique exposures to thyroid preparations only 3 cases had major adverse outcome and there were no deaths[4]. It has been documented that there is no correlation between the amount of levothyroxine ingested and the onset and severity of the symptom...

Case 1 An 80 year old woman with advanced thyroid cancer had maintained suppressed concentrations of thyroid stimulating hormone and stable free thyroxine by taking 125 g levothyroxine daily. She was admitted with a pathological fracture of the femur and complicating osteomyelitis. After four weeks’ treatment with oral ciprofloxacin (750 mg twice a day), intravenous dicloxacillin, and subcutane...

BACKGROUND There is wide agreement that thyroid hormone replacement should not be given in doses sufficient to suppress thyroid-stimulating hormone (TSH). The purpose of our study was to determine the prevalence of patients currently taking levothyroxine who have an inappropriately suppressed TSH and are thereby at risk for complications of overt or subclinical hyperthyroidism. Those complicati...

OBJECTIVES To evaluate the association between thyroid autoantibodies and miscarriage and preterm birth in women with normal thyroid function. To assess the effect of treatment with levothyroxine on pregnancy outcomes in this group of women. DESIGN Systematic review and meta-analysis. DATA SOURCES Medline, Embase, Cochrane Library, and SCISEARCH (inception-2011) without any language restric...

context appropriate management of neonates, tested positive for congenital hypothyroidism (ch), in particular, the initial dosage of levothyroxine and the time of initiation of treatment is a critical issue. the aim of this study was to assess all current evidence available on the subject to ascertain the optimal initial dose and optimal initiation time of treatment for children with ch. eviden...

BACKGROUND Suboptimal thyroid hormone therapy including under-replacement and over-replacement is common amongst patients with hypothyroidism. This is a significant health concern as affected patients are at risk of adverse cardiovascular or metabolic consequences. Despite a growing body of evidence on the effects of various factors on thyroid hormone replacement, a systematic appraisal of the ...